ABSTRACT
Abnormal fatty acid metabolism is one of the unique metabolic ways in which malignant cells maintain their growth needs and plays a crucial role in tumor progression.Acetyl-CoA carboxylase (ACC) is the rate-limiting enzyme in fatty acid synthesis and oxidative metabolism.More and more researches confirm that ACC is highly expressed in many tumors,and is closely related to tumor progression and prognosis of patients,which makes ACC as a potential marker for clinical diagnosis and prognosis.Tumor cell fatty acid synthesis can be blocked and fatty acid β oxidation can be stimulated by inhibiting the activity of ACC,resulting in serious lipid consumption of tumor,and then inhibit tumor growth and proliferation.Investigating the effect and molecular mechanisms of ACC in the genesis and development of tumors can provide a new insight into cancer targeted molecular therapy.
ABSTRACT
Objective To explore the effects of improved intubation in preventing accidental PICC intubation into internal jugular vein. Methods 180 patients with PICC were randomly divided into two groups:control and trial group.In the control group, the routine intubation with head sided was performed,and in the trial group,the intubation was done with gauze of different size accord-ing to the space between the neck and shoulder pressed downward and inward at the spot of internal jugular vein to the bottom and meanwhile having the patient turn the head aside and press the gauze with their draw when the tube head was inserted 15 cm deep.The two groups were compared in terms of the rate of PICC intubation into internal jugular vein.Result The incidence of catheterization by accident into the internal jugular veinin the trial group was significantly lower than that of the control group (P＜0.05). Conclusion The intubation with gauze pressed at the internal jugular vein can obviously reduce the incidence of catheterization by accident into the internal jugular vein.This method is worthy of clinical popularization and application.
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Objective To investigate the effect of nutritional guidance on the energy intake and body weight of patients with gastric cancer chemotherapy. Methods The experimental study was used to study the 144 cases with gastric cancer for the first time of chemotherapy. They were randomly divided into the experimental group and the control group, 72 cases in each group. Routine healthy guidance was used in the control group, while the patients in the experimental group were treated by the nutrition prescription, the nutrition guidance, the purpose and the significance of the chemotherapy, and the follow-up of the patients after discharge. The body weight of patients was collected before chemotherapy, and the dietary questionnaire was used for second days after first days of dietary intake, and the changes of energy consumption and body weight were compared between the two groups. Results The mean values of energy intake within 24 hours in the first 3 days after the chemotherapy in the experimental group was 5 068.92 kJ, which was 51%of the RNI. The mean values of energy intake within 24 hours in the first 3 days after the chemotherapy in the control group was 3 439.25 kJ, which was 38%of the RNI. The difference between the two groups was significant (P<0.01). The weight of patients in the experimental group at the time point of before the 5th and 6th time of chemotherapy were significant higher than those in the control group (P<0.05). Energy intake had influenced the patients′weight, high energy intake with low decrease of body weight. Conclusions Nutritional guidance can effectively improve the energy intake of patients with gastric cancer when chemotherapy, so that the weight remained stable during chemotherapy.
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Objective To explore the effect of nursing instruction on the compliance of patients with gastric cancer after chemotherapy. Methods Selected 144 patients who had underwent surgey for gastric cancer after the first chemotherapy from May 2013 to December 2014. Randomly divided into experimental group and control group, Health education for patients in the control group during the period of hospitalization and before discharge. Follow up the implementation of the first chemotherapy after the first follow-up nursing guidance. Patients in the experimental group on the basis of the implementation of the whole process of continuing nursing guidance, including the increase in the duration of hospitalization, nutrition education, nutrition, prescription and adverse drug reaction to respond to chemotherapy. After each chemotherapy, the telephone follow-up was carried out to guide the treatment of nutritional intake and adverse effects of chemotherapy, emphasizing the importance of chemotherapy. The chemotherapy compliance of the two groups were compared. Results The median number of chemotherapy in the experimental group was 6, while that was 4.5 in the control group, the difference was statistically significant, Z=2.672, P=0.008. The adverse reaction was the main reason for the loss of patients with chemotherapy, the drop rate in the control group because of adverse reaction of chemotherapy was higher than that of in the experimental group, χ2=3.973, P=0.046, the difference was statistically significant. Conclusions Due to serious adverse reactions in patients with gastric cancer after operation, chemotherapy confidence needs to be strengthened. The whole process of continuous nursing guidance is conducive to the patient′s chemotherapy confidence, improve the patient's chemotherapy compliance.
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Objective To study the effect of modified air bag deflation lubrication by Sengstaken-Blakemore tube on voluntary dysphagia induced by esophageal variceal bleeding.Method Twenty seven patients with voluntary dysphagia induced by esophageal and gastric variceal bleeding were managed with modified air bag deflation lubrication with Sengstaken-Blakemore tube.Results The indwelling time for the Sengstaken-Blakemore tube was 3~6 d.There was no complication of gastrointestinal mucosal injury and aspiration complications.Conclusion The modified air bag deflation lubrication by Sengstaken-Blakemore tube may effectively avoid the complications by hemostasis with Sengstaken-Blakemore tube.