ABSTRACT
OBJECTIVE@#To investigate the changes of leukotriene D4 (LTD4) in nasal discharge and plasma of patients with persistent allergic rhinitis (AR) and the effects of antihistamine.@*METHOD@#The investigation was a prospective, randomized controlled trial. Forty AR patients (group C) were divided randomly into two subgroup. One group received oral antihistamine 10 mg everyday for one week (group CA) and another group received no loratadine tablets 10 mg everyday for one week (group CB). Fifteen age matched healthy (group D) people were enrolled as control. The level of LTD4 and interleukin-5 (IL-5) in both nasal discharge and plasma by using enzyme linked immunosorbent assay (ELISA) and enzyme immunoassay (EIA), cell counts and cell differentials in nasal discharge, were measured before and after three month. The clinical symptom and life quality scores of group C were also investigated.@*RESULT@#The concentrations of LTD4 in nasal discharge [(794 +/- 305) pg] and plasma [(5219 +/- those in group D [(347 +/- 169) pg, (2283 +/- 489) ng/L, all P 1185) ng/L] in group C were significantly higher than those in group D [(347 +/- 169) pg, (2283 +/- 489) ng/L, all P 0.05).@*CONCLUSION@#The results suggested that LTD4 was involved in airway inflammation in AR. Antihistamine was not effective enough in decreasing the levels of LTD4 in both nasal discharge and plasma of AR patients.
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Anti-Allergic Agents , Pharmacology , Bodily Secretions , Chemistry , Histamine H1 Antagonists , Pharmacology , Leukotriene Antagonists , Therapeutic Uses , Leukotriene D4 , Blood , Metabolism , Plasma , Chemistry , Prospective Studies , Rhinitis, Allergic, Perennial , Blood , Drug Therapy , MetabolismABSTRACT
0.05). Furthermore, the severity of painful feeling occurred during packing and withdrawing of packing material was also much less severe in the group of cases packed with Merocel than in those with vaseline gauze. It is concluded that the using of Merocel highly expansive sponge is an effective material and usable for nasal packing in epistaxis.
ABSTRACT
Auricle reconstruction involves auricular framework construction and selection of skin soft tissues that coats the auricular support. To date, there has no ideal biomaterial for the auricular framework. The materials of auricular framework include autologous costal cartilage, medical grade silicon rubber, and porous polyethylene. The autologous costal cartilage avoids rejection, and has advantages such as good flexibility, easy combination with surrounding coated tissues, and low surgical cost. However, the acquisition causes injury, increases pain of patients, alters thoracic cage structure, and the cartilage graft is absorbable and deformable. The medical grade silicon rubber exhibits good exposure rate and high inflammation, which limit its clinical application. Medpor implant has been used recently as novel medical chemical synthesis materials. It makes of high density polyethylene, with strong plasticity, time-efficacy, stable fusion with local tissue and good biocompatibility. However, the exposure of Medpor implant is the complication. In this study, the Medpor implant in combination with total auricle reconstruction was used to treat 12 cases of congenital microtia, trauma-induced auricular defect, auricular defect complicated by atresia of external auditory canal and hearing disturbance. Postauricular fascial flap was expanded to form reconstructed auricle, followed by wound skingrafting. The expanded fascial flap improves blood supply, with close coating, decreases complications. Moreover, all reconstructed auricle survived, with no ulcerate or exposure, and the appearance is similar to normal auricle.
ABSTRACT
To investigate the curative effect of Medtronic merocel packing after endoscopic sinus surgery,76 patients underwent endoscopic sinus surgery in the Department of Otolaryngology,Xiangfan Hospital,Tongji Medical College,Huazhong University of Science and Technology from June to December in 2004,were adopted in this study and randomly divided into two groups:36 cases in observation group were packed with Medtronic merocel sponge,40 cases in control group with Vaseline gauze,the nasal pain and haemostasis effect after the package removal were observed.The result showed that,the incidence rate of nasal pain and haemostasis in the observation group was significantly lower than that in the control group(P