ABSTRACT
Objective To observe the effect of olopatadine in the treatment of allergic conjunctivitis.Methods 67 cases with allergic conjunctivitis were randomly divided into 2 groups.The observation group was given 0.1％ hydrochloride olopatadine eyedrop twice a day for 7 days,while the control group was given 2％ cromolyn sodium 4 times a day for 7 days.One hour,7 days,20 days after treatment,the changes of symptoms and the incidence of adverse reactions were observed.Results 7 days after treatment,the totsl effective rate of the observation group in treatment of eye itching,conjunctival hyperemia and conjunctiva nipple were 91.18％,91.18％ and 85.19％,better than that of the control group[ 72.7％,75.76％,85.19％ ( all P ＜ 0.05 ) ].Conclusion It's rapid onset long duration of action and high security that olopatadine in the treatment of allergic conjunctivits,and it was worthy to promote to be used in clinic.
ABSTRACT
Objective To make a rapid determination of ferulic acid and identification of its structure in rhizome of Phragmites communis (RPC). Methods The chemical constituents were extracted by solvent and the relative content and structure of ferulic acid in RPC were determined and identified using GC-TOFMS technique. Results By GC-TOFMS, the ferulic acid was successfully isolated from the extracts of RPC in a relative content of 5%. According to the exact masses and corresponding elemental compositions of molecular ion and eight characteristic ions, a possible fragmentation pathway of the ferulic acid molecule was proposed, by which the molecular structure was confirmed. Conclusion GC-TOFMS technique is a rapid, accurate, sensitive, and reliable method for determination of the relative content of ferulic acid in RPC and identificatiion of its structure.
ABSTRACT
AIM: To further investigate preventive effects of Shenfu(SF) injection, a Chinese herb drug, on acute renal ischemic reperfusion injury (IRI). METHODS: After SF or normal saline was administered intravenously one time a day for four days, the renal ichemia-reperfusion(I-R) model was established by occlusion of right renal artery and vein for an hour and reperfusion for three hours after left nephroectomy. The activity of superoxide dismutase (SOD), content of malondialdehyde(MDA) in serum and renal tissue, and content of nitric oxide (NO),concentrations of Na + and Ca 2+ , numbers of WBC adhesion in renal tissue were detected and light and electronic microscopy were used for the detection of the renal histological changes. RESULTS: SF lowered significantly MDA content in either renal tissues or serum , concentration of Na +, the number of WBC adhesion, and scores of tubules in renal tissue after renal I-R, and the SOD activity in renal tissues and serum and NO content in renal tissue were obviously increased by SF.In addition,renal histomorphological damage in either light or electronic microscope were lightened by SF. But Ca 2+ concentration in renal tissue appeared to be only mildly affected. CONCLUSION: The mechanisms that SF protects renal structure and function against acute renal IRI may be involved in increasing SOD activity,scavenging directly oxygen free redicals(OFR),raising NO content,inhibiting WBC adhesion and recruiment,preventing Na + influx to form Na + overload.