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Objective:To investigate the normal range of fetal ventricles and posterior cranial fossa development in the second and third trimesters and their variations with gestational age using quantitative MRI analysis.Methods:This retrospective study enrolled 675 pregnant women who underwent prenatal MRI examination with an average gestational week of 29.0±8.5 in the Third Affiliated Hospital of Guangzhou Medical University from January 2016 to January 2020. MRI data of all the subjects were collected and analyzed, including left lateral ventricle trigonometric width (LLVTW) and right lateral ventricle trigonometric width (RLVTW), third ventricle width (TVW), fourth ventricle width (FVW), the anterior-posterior diameter of the fourth ventricle (APDFV), cavum septum pellucidum width (CSPW), cisterna magna width (CMW), etc. Spearman, Pearson correlation analysis, and t-test were used for the statistical analysis. Results:(1) Totally 675 fetuses were recruited, including 392 female and 283 male fetuses. No statistical difference of gestational weeks at MRI was found between male and female fetuses. (2)The mean value of TVW and CMW of the female fetuses were significantly higher than those of male fetuses [(0.60±0.05) vs (0.63±0.04) cm, t=－5.059; (0.57±0.14) vs (0.67±0.15) cm, t=－7.445; both P<0.001]. Spearman correlation analysis showed that TVW and CMW were negatively correlated with fetal gender ( r=－0.179 and－0.312, both P<0.001). (3)Pearson correlation analysis showed that LLVTW, RLVTW, TVW, FVW, APDFV, CSPW, and CMW were all positively correlated with gestational weeks ( r=0.310, 0.267, 0.205, 0.801, 0.829, 0.216 and 0.284, all P<0.001). FVW and APDFV were significantly linearly correlated with gestational weeks (r=0.801 and 0.829, both P<0.001). (4) There was no significant change in LLVTW and RLVTW in the second trimester, but a slight increase was found in the third trimester. TVW showed a scattered distribution in the second and third trimesters and increased slightly with the gestational week at 26 to 27 +6 gestational weeks. FVW and APDFV increased linearly while. CSPW increased slowly with gestational weeks in the second and third trimesters. CMW increased slightly with gestational weeks in the second and third trimesters but showed little change in the third trimester. Conclusions:The development of fetal ventricles and posterior cranial fossa in the second and third trimesters show a growth trend of varying degrees with the increase of gestational weeks. TVW and CMW are significantly negatively correlated with the fetal gender.
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【Objective】 To study the serological and genetic characteristics of a case of B(A) blood group. 【Methods】 Serological and genetic ABO blood group typing were used to analyze the ABO subtype and family inheritance of the probands and her 8 family members. The B(A) blood type sample was used as the blood recipient, and the B-type and O-type donors were selected for cross-matching using microcolumn gel anti-human globulin method to evaluate the blood transfusion strategy. 【Results】 5 out of 9 family blood samples were B(A) phenotype, carrying B(A)04 allele. Among them, 1 was B(A)04/O1 type, and 4 were B(A)04/B type. The primary blood matching of B(A) blood type samples with type B and O recipients were all negative. 【Conclusion】 A total of 5 cases of B(A)04 blood type were found in this family investigation, and there were differences in serological manifestations. Washed RBCs with B and O type can be used for B(A) blood type transfusion, and type B suspended RBCs can be considered in case of emergency.
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Objective To evaluate the value of 3.0 T dynamic contrast-enhanced magnetic resonance imaging(MRI) in the diagnosis of hip joint lesions in patients with ankylosing spondylitis (AS).Methods Fifty-two AS patients with hip involvement were diagnosed in Department of Rheumatology in our hospital from January 2013 to December 2016.All patients underwent AS disease activity ankylosing spondylitis disease activity score (ASDAS)-C-reactive protein (CRP) score evaluation of hip joint acti-vity and hip joint disease activity was evaluated by doctors.According to ASDAS-CRP score,patients were divided into active disease 34 cases and remission for 18 cases.All patients underwent double hip MRI plain scan,dynamic enhanced scan and post-processing analysis after the diagnosis.Six regions of interest were selected in the abnormal synovial area around the hip joint.The time signal TIC curve was generated automatically,the shape of the curve was described and the early intensification rate of the third,fourth phase was measured.The early intensification rates of the active disease group and the remission group were analyzed statistically.Two independent samples t test was used for analysis,and P＜0.05 was regarded as statistically significant.The early intensification rate of the third,fourth phase were compared with the ASDAS-CRP score,the evaluation of hip joint activity in patients and the evaluation of hip joint activity were carried out by doctors taking care of the patients.Results The TIC curve of the active group was rising fast,followed by platform or fast rising.The curve of the remission group was slow rising.The inten-sification rate of the third,fourth phase [(116±9)％,(146±12)％ respectively] in the active phase group was higher than that of the remission group [(23±5)％,(43±14)％],and the difference was statistically significant (t=2.447,3.054;P＜0.05).The rate of synovial enhancement of the third,fourth phases was positively correlated with the ASDAS-CRP score (r=0.802,0.836,P=0.01),and the correlation was poor with evaluation of hip joint activity by patients (r=0.352,0.458;the P=0.02,0.01respectively),and the correlation was goodwith the evaluation of hip joint activity by doctors (r=0.652,0.717;P=0.01).Conclusion The shape and early enhancement rate of magnetic reson-ance dynamic enhanced TIC curve is valuable in assessing the disease activity of hip joint lesions in AS patients.
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Objective To investigate the relationship between single b-value and multiple b-value diffusion weighted imaging (DWI)and different types of breast lesions.Methods The data of 92 cases including 8 cases of cyst,11 cases of granulomatous inflammation,33 cases of benign nodules lesions and 40 cases of malignant tumor were analyzed retrospectively,who underwent single b-value DWI and multiple b-value DWI and all patients were confirmed by pathology.The normal side of the mammary gland fiber was taken as the control group.Apparent diffusion coefficient(ADC)were obtained by the monoexponential model.Slow apparent diffusion coefficient(ADCslow),fast apparent diffusion coefficient(ADCfast),the fraction of fast ADC(ffast)were obtained by the biexponential model.ADC,ADCslow,ADCfast,ffastvalues of different breast lesions were analyzed by single factor analysis of variance.The LSD-t test was used to compare the mean values of the parameters of the breast lesions in pairs.Results The ADC and ADCslowvalue of breast lesions were decreased in the order of cyst (2.369 ± 0.380)×10-3mm2/s,(1.294 ± 0.439)×10-3mm2/s,normal gland(1.785 ± 0.298)×10-3mm2/s,(0.946 ± 0.321)×10-3mm2/s,benign tumor(1.647 ± 0.296)×10-3mm2/s,(0.944 ± 0.256)×10-3mm2/s,malignant tumor(1.146 ± 0.191)×10-3mm2/s,(0.584 ± 0.139)×10-3mm2/s and mastitis(1.062 ± 0.231)×10-3mm2/s,(0.567 ± 0.115)×10-3mm2/s.The ADCfastvalue of malignant group(4.445 ± 1.616)×10-3mm2/s was significantly higher than that of other groups,and the difference was statistically significant.The ffastvalue of malignant group 0.364 ± 0.148 was significantly lower than that of benign group,normal gland and cyst.ADCfastvalue in the inflammatory group(3.321 ± 0.660)× 10-3mm2/s was significantly lower than that in the malignant group,and the difference was statistically significant.There was no significant difference in ADC,ADCslowand ffast.Conclusion Compared with the single b-value DWI,the parameters of multiple b-value DWI reflected the pathological features of different breast lesions better.The value of ADCfasthas higher diagnostic value in the identification of mastitis and breast cancer.