ABSTRACT
The mesenchymal stem cell ( MSC ) is an important component of the hematopoietic microenvironment .In the process of stem cell transplantation (SCT), MSC can restore the hematopoietic microenvironment , improve the capacity of hematopoiet-ic reconstitution, reduce the incidence of graft versus host disease (GVHD).MSC has been widely used in hematopoietic stem cell transplantation, immune therapy, tissue engineering and many other fields .The distribution and colonization of MSC in vivo directly af-fect the effectiveness of transplantation .Improving the homing and engraftment of MSC may obtain a better therapeutic effect .Further research on the mechanism and influential factors of MSC homing may lead to the development of therapies and promote clinical applica -tions of MSC.This paper reviews the recent progress in homing mechanism of MSC .