ABSTRACT
Objective To study the anti-lipid peroxidation effect of seal oil on rat liver steatosis induced by carbon tetrachloride and high fat diet and its mechanism of action. Methods: Both sc a low dose of carbon tetrachloride and high fat diet were given to male Wistar rats for 7 weeks . Then five groups(n=10 in each) received olive oil, simvastatin 4 mg ? kg-1 ? d-1, seal oil 0. 5, 1. 6, 4. 8 g ? kg-1 ? d-1 , administered orally for further 8 weeks,respectively . The untreated control group received only normal feed. The efficacy of seal oil on fatty liver and anti-lipid peroxidation was observed. Results: The contents of MDA and FFA decreased, CYP2E1 expressed weakly and SOD increased significantly in seal oil groups while hepatic TC,TG decreased and fatty liver was markedly improved when tested by pathologic diagnosis. Conclusion: Seal oil can induce SOD activities and eliminate oxygen free radical, thus show anti-lipid peroxidation effects on experimental fatty liver.