ABSTRACT
No abstract available.
Subject(s)
Female , Humans , Male , Young Adult , Base Sequence , Cell Cycle Proteins/genetics , Chromosomes, Human, Pair 11 , Chromosomes, Human, Pair 22 , Gene Rearrangement , Histone-Lysine N-Methyltransferase/genetics , Immunophenotyping , In Situ Hybridization, Fluorescence , Karyotype , Leukemia, Myeloid, Acute/diagnosis , Myeloid-Lymphoid Leukemia Protein/genetics , Oncogene Proteins, Fusion/genetics , Reverse Transcriptase Polymerase Chain Reaction , Septins/genetics , Sequence Analysis, DNA , Translocation, GeneticABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical and genetics characteristics of patients with monosomal karyotype acute myeloid leukemia (MK-AML).</p><p><b>METHODS</b>The karyotypes of 3743 patients with newly-diagnosed de novo AML were analyzed, which had identified 153 cases with MK-AML, for whom the clinical and genetics characteristics were analyzed.</p><p><b>RESULTS</b>There were 2056 patients (54.9%) among all patients. A total of 153 patients fulfilling the criteria for MK-AML were identified, which comprised 93 males and 60 females, with a median age of 54. The median white blood cell count on presentation was 4.4×10 (9)/L. One hundred and forty-five cases (94.8%) have fulfilled the criteria for complex karyotype (≥ 3 chromosomal abnormalities). Although the monosomy could be found with all autosomes, chromosome 7 has been most frequently involved (38.56%, 59/153).</p><p><b>CONCLUSION</b>MK-AML is a distinct cytogenetic subtype of AML. Monosomy 7 is frequently detected among MK-AML patients. The monosomal karyotype is common among elder patients with AML.</p>