ABSTRACT
The immunopharmacological effects of anisodamine(654-2)on immune complexnephritis were examined in rabbits with acute experimental serum sickness(AESS).The results showed that activities of renal calmodulin(CaM)and cathepsin D(Cath-D)were significantly high.654-2 could inhibit CaM activity and immune complex-induced lysosomal enzyme release,and lessen immune complex glomerulonephritis at thesame time.Our findings suggest that a marked inhibition of CaM activity by 654-2 mi-ght contribute greatly to the improvement of immune complex glomerulonephritis.
ABSTRACT
Anisodamine (654-2) was administered to rabbits with acute experimental serum sickness (AESS) to study the immunomodulatory effects of 654-2 on AESS. The results suggested that 654-2 may decrease the serum specific antibody and immune complex (IC), inhibit the activity of serum cathepsin D (Cath-D), make the level of complemnts in narrow change, and improved the renal injury.