ABSTRACT
Serum butyrylcholinesterase activity has been al a biomarker for indentification of organophosphate poisoning. The reduction of serum butyrylcholinesterase activity is found in acute to chronic exposure cases of the pesticide. To evaluate the health impact on pesticide exposure, serum butyrylcholinesterase activity in tobacco agricultural workers as an experimental group (n=100) was to non-exposed subjects (n=80). Serum butyrylcholinesterase activity was measured using propionylthiocholine activity was measured using propionylthiocholine as substrate and performed on DataPro automatic analyzer. Liver enzymes activities of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were also analyzed to evaluate liver damage. Average butyrylcholinesterase activities of 5,083 U/L ranged 2,037-7,169 U/L) and 5,692 U/L (ranged 3,217-7,655 U/L) were found in experimental and control group, respectively. A comparison between groups revealed that BchE activity was significantly reduced in experimental group (P
ABSTRACT
Background and objective : Glycosylation index is composed of glycosylation gap (GG), hemoglobin glycation index (HGI), fructosamine glycation index (FGI).\ The indeces are index calculated based on blood glucose (BG), fructosamine (F), and glycated hemoglobin (HbA1C).\ The purpose of this study was to compare these indices in type 2 diabetic patients (T2DM) with various\ stages of nephropathy.Methods:\ HbA1C, BG and F were obtained from 104 T2DM patients (37 males, 67 females) at a single clinical visit at Buddhachinnaratana Hospital, Pitsanulok.\ The stages of nephropathy was divided into 3 groups according to albuminuria level; no nephropathy (n = 57), microalbuminuria (n = 29), and advanced nephropathy (n = 18).Results : Mean\±SD HbA1C = 7.9\±1.7%, F = 279\±69 mol/L, BG = 7.0\±1.9 mmol/L, GG = 0.0\±2.37, HGI = -0.23\±1.47, and FGI = -0.21\±63 were found in all subjects.\ Mean GG (0.55\±0.8), HGI (0.70\±1.5), and HbA1C (9.0\±1.8%) in patients with advanced nephropathy was significantly different from those with no nephropathy and microalbuminuria (P \< 0.05),Conclusions :\ Increasing levels of HbA1C indicate with worsening nephropathy in T2DM.\ Key words: Glycosylation index; type 2 diabetes mellitus; Microalbuminuria; Nephropathy\
ABSTRACT
Pseudohyperkalaemia refers to an elevation of potassium level in the specimen (in vitro), but a potassium level in the body (in vivo) is normal. This elevation is found without any clinical manifestation. Pseudohyperkalaemia is a common problem found in clinical laboratory due to the inconsistency of serum potassium with the clinical picture. The focuses of this review are to summarize causes of pseudohyperkalaemia and to propose a guideline for validation of abnormal potassium result. A high level of awareness is required to manage the risk of misinterpretation and improper patient management.
ABSTRACT
Zinc is an essential micronutrient for spermatogenesis and normal sperm function. However, the correlation of zinc level in seminal plasma and the results of semen analysis is controversial. This study aimed to evaluate zinc levels in seminal plasma of infertile men. One hundred thirty five left-over semen of infertile men collected from the Reproductive Biology Unit, Department of Obsterics and Gynecology, Faculty of Medicine, KKU were analyzed for semen analysis. The seminal plasma was then classified into 2 groups according to its results of semen analysis. Normal group was named normozoospermia (n = 61). The samples classified as oligospermia, asthenozoospermia, oligoasthenozoospermia, and azoospermia were included in abnormal group (n = 74). They were used for zinc determination by atomic absorption spectrophotometer. Zinc levels of normal and abnormal group were 14.21 mg% and 14.72 mg% , respectively. Mean values of zinc level in two groups were significantly different (P \< 0.001) with 95 % CI of 11.75-16.68 mg% for normal group, and of 12.64-16.81 mg% for abnormal group. The results implied that determination of zinc level in seminal plasma of infertile men might not be very useful due to a miniscule difference mean value of this ion in both groups. Further study of zinc contents should be investigated in subgroup of semen analysis, or in comparing of fertile and infertile men.