ABSTRACT
<p><b>OBJECTIVE</b>To investigate the development, distribution and GLUT-1 expression of infantile hemangioma and to discuss the early surgical intervention for better results and avoiding severe complication.</p><p><b>METHODS</b>The lesion site of each case was recorded and analyzed by SPSS V13.0 to study the distribution. The operation was guided by the principle of plastic surgery to remove the hemangioma. The GLUT-1 expression was detected by immunohistochemical technique in all the resected samples.</p><p><b>RESULTS</b>All the results were satisfactory. The GLUT-1 expression was positive in all the cases. The incidences in different sites were significantly different (P < 0.05). 71.7% of the hemangiomas were located at upper and lower lip, periorbital region and facial midline. It indicates that hemangioma is not randomly distributed. Most of them were located at the fusion of facial prominences during embryological development.</p><p><b>CONCLUSIONS</b>Infantile facial hemangioma maybe originated from endothelial progenitor cells of placenta which migrate and implant on the fusion of facial prominences. Early surgical intervention is one of the best choice for infantile facial hemangioma.</p>