ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of acupuncture on the immune function of patients with colorectal cancer liver metastasis.</p><p><b>METHODS</b>Sixty cases with colorectal cancer liver metastasis confirmed by pathology and mageology diagnosis were treated with acupuncture. Zusanli (ST 36), Sanyinjiao (SP 6), Neiguan (PC 6), Shangjuxu (ST 37), Hegu (LI 4), Taixi (KI 3), Taichong (LR 3) ,Yinlingquan (SP 9), Yanglingquan (GB 34), etc. were selected for acupuncture, and Shenque (CV 8), Guanyuan (CV 4), Qihai (CV 6), Zusanli (ST 36) were selected for moxibustion. The changes of CD(3) , CD(4) , CD(8) T cells and NK cells in value were examined with flow cytometry before and after treatment.</p><p><b>RESULTS</b>The value of T lymphocyte subsets such as CD(3) , CD(4), and CD(8) , as well as NK cells were obviously increased after treatment, and there were significant differences between them before and after treatment.</p><p><b>CONCLUSION</b>Acupuncture can improve the immune function of patients with colorectal cancer liver metastasis.</p>
Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Acupuncture Therapy , Colorectal Neoplasms , Allergy and Immunology , Pathology , Therapeutics , Killer Cells, Natural , Allergy and Immunology , Leukocyte Count , Liver Neoplasms , Allergy and Immunology , Pathology , Therapeutics , Neoplasm Metastasis , T-Lymphocyte Subsets , Allergy and ImmunologyABSTRACT
<p><b>OBJECTIVE</b>To study the therapeutic effect of intravenous high-dose vitamin C on implanted hepatoma in rats.</p><p><b>METHODS</b>The rats bearing implanted Walker-256 hepatoma were treated with high-dose vitamin C at 2.83 and 5.65 g/kg intravenously, and the general condition, liver functions (A/G, ALT, AST, GGT), tumor volume, and tumor growth of the rats were evaluated.</p><p><b>RESULTS</b>The A/G of the rats treated with 2.83 g/kg vitamin C was significantly higher, but the ALT and GCT were significantly lower than those of the model rats (P<0.05 or 0.01). The ALT level in rats with 5.65 g/kg vitamin C treatment was significantly lower than that of the model rats (P<0.05). The tumor necrosis rate was significantly higher in rats with 2.83 g/kg vitamin C treatment than in the model rats (P<0.05).</p><p><b>CONCLUSION</b>Intravenous administration of 2.83 g/kg vitamin C can promote the necrosis and apoptosis of hepatoma Walker256 cells in rats and protect the liver function of the tumor-bearing rats.</p>