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Objective To compare the differences in plantar kinetics between older male adults and young male adults during walking, and to explore the influences of aging on plantar kinetics. Methods The in-shoe plantar sensory measurement system was used to collect and compare left foot parameters of 13 older men and 14 young men during tandem walk, including contact time, beginning of contact in percentage of roll over process (%ROP), and end of contact in %ROP, peak pressure, instant of peak pressure in %ROP, maximum mean pressure, pressure-time integral, maximum force, instant of maximum force in %ROP, mean force and force-time integral. Results Beside media arch, the contact time on all regions of older men was longer, whereas, the beginning of contact in %ROP on lateral heel, lateral arch was greater, and the end of contact in %ROP on medial heel and 2nd-3rd metatarsal head was smaller compared with young men. The maximum force and mean force on the whole foot region, and the maximum mean pressure and maximum force on 2nd-3rd metatarsal head of older people were significantly lower; the pressure-time integral on the whole foot region, the 4th-5th metatarsal head, the 2nd -5th toes, and the force-time integral on the whole foot region, medial heel, lateral heel and 2nd -5th toes were significantly higher compared with young men. Conclusions During tandem walking, plantar fascia dysfunction might be one of the main reasons for the decline of postural control ability, and the contraction enhancement of flexor digitorum longus and flexor digitorum brevis could compensate for postural stability improvement in older men.
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Objective To compare the differences in long-term jogging and Tai Chi in terms of neuromuscular latency and time to peak of surface electromyography (EMG) in older males during lateral sudden perturbation. In addition, an effective means to enhance neuromuscular response and muscle contraction efficiency of older males during lateral postural challenges was investigated. Methods Postural reactions of young males, older sedentary male controls (without regular exercises), older male joggers (with long-term jogging practice), and older male Tai Chi participants (with long-term Tai Chi practice) were evoked by means of a sudden unpredictable lateral translation platform. Surface EMG signals of peroneus longus, anterior tibialis, gluteus medius, and erector spinae were collected by an EMG detection and analysis system. Results The latencies of peroneus longus, anterior tibialis, and gluteus medius were delayed in the older sedentary male controls compared with those in young males. The neuromuscular reactions of anterior tibialis and erector spinae in older Tai Chi male participants were faster than those of older sedentary male controls. The contraction speeds of peroneus longus, anterior tibialis, and gluteus medius in young males were higher than those in three older groups during sudden lateral perturbations. Conclusions Long-term Tai Chi practice can enhance the responses of ankle and trunk muscles of older males during lateral postural challenges, but it has little effect on the muscle contraction efficiency of older males.
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Objective:To investigate the health - related quality of life of rural residents in Shandong Province and analyze its influencing factors. Methods:EQ - 5D scale was used to measure the health - related quality of life of rural residents in Shandong Province,and Chi - square test,t test and multiple linear regression were used to ana-lyze its influencing factors. Results:The main health problems of rural residents in Shandong Province were pain /discomfort,and the score of EQ - VAS of surveyed population was(82. 78 ± 15. 68). The health - related quality of life of rural women was poor; the abilities of action,self - care,and daily activities of residents above 60 years old declined sharply,and subjects with no spouse and low level education faced more health problems. Age and chronic disease were the major factors that influenced quality of life. Conclusion:Grasping the life quality characteristics of different age groups and strengthening the prevention and control of chronic diseases in rural areas are of great sig-nificance for effectively improving the health - related quality of life of rural residents in Shandong Province.
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Objective To analyze the changes of age, sex, and urban-rural characteristics of inpatients with malignant tumors in Shanxi Cancer Hospital from 2005 to 2014. Methods The data of malignant tumor patients from January 2005 to December 2014 in Shanxi Cancer Hospital were analyzed, which were stratified by age, sex and residence. SAS 9.2 statistical software was used to analyze the changes of age, sex and residence of patients with malignant tumors. Results The average age of malignant cancers was 59.16-60.99 years old for men and 50.7-52.06 years old for women from 2005 to 2014. The incidence between male and female was decreased from 0.81 in 2005 to 0.71 in 2014. The incidence ratio of urban-rural was decreased from 3.5 in 2005 and 2.13 in 2014. The disparities in urban-rural areas still existed in recent 10 years.The incidence number of women in rural areas and the average age of malignant tumors in our hospital was increased significantly respectively. Lung cancer, breast cancer, cervical cancer, esophagus cancer and stomach cancer were the major cancers. The incidence of lung cancer ranked in the first place in male tumors, and the breast cancer ranked in the first place for female tumors. Conclusions It still exists gender and urban-rural differences in patients with malignant tumors in Shanxi Cancer Hospital from 2005 to 2014, and aging tends to be more obvious. The prevention and control of lung cancer, digestive system cancer, female breast cancer are the emphasis in Shanxi Province, while the promotion of health education intervention should be undertaken. Besides, other kinds of comprehensive prevention and control measures are necessary including the screening for major cancers in key areas and the early diagnosis.
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Objective To analyze the changes of age, sex, and urban-rural characteristics of inpatients with malignant tumors in Shanxi Cancer Hospital from 2005 to 2014. Methods The data of malignant tumor patients from January 2005 to December 2014 in Shanxi Cancer Hospital were analyzed, which were stratified by age, sex and residence. SAS 9.2 statistical software was used to analyze the changes of age, sex and residence of patients with malignant tumors. Results The average age of malignant cancers was 59.16-60.99 years old for men and 50.7-52.06 years old for women from 2005 to 2014. The incidence between male and female was decreased from 0.81 in 2005 to 0.71 in 2014. The incidence ratio of urban-rural was decreased from 3.5 in 2005 and 2.13 in 2014. The disparities in urban-rural areas still existed in recent 10 years.The incidence number of women in rural areas and the average age of malignant tumors in our hospital was increased significantly respectively. Lung cancer, breast cancer, cervical cancer, esophagus cancer and stomach cancer were the major cancers. The incidence of lung cancer ranked in the first place in male tumors, and the breast cancer ranked in the first place for female tumors. Conclusions It still exists gender and urban-rural differences in patients with malignant tumors in Shanxi Cancer Hospital from 2005 to 2014, and aging tends to be more obvious. The prevention and control of lung cancer, digestive system cancer, female breast cancer are the emphasis in Shanxi Province, while the promotion of health education intervention should be undertaken. Besides, other kinds of comprehensive prevention and control measures are necessary including the screening for major cancers in key areas and the early diagnosis.
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To improve the water solubility of daidzein, solid inclusion complexes of daidzein with two amino-modified β-cyclodextrins (ACDs), i.e., mono-6-amino-6-deoxy-β-cyclodextrin (NCD) and mono-6-ethylenediamino-6-deoxy-β-cyclodextrin (ENCD), were prepared by the saturated solution method in water under the preparation conditions as follows: the ratio of daidzein/ACD was 3∶1 and the stirring time was 72 h (83% and 67% yields, respectively).The formation of two inclusion complexes was confirmed by x-ray diffractometry (XRD) and themogravimetric (TG) analysis.The inclusion stoichiometry of the inclusion complexes was 1∶1 from the Job plot and their complexation stability constants (KS) were 899.2 and 203.8 L/mol from fluorescence titration, respectively.After formation of inclusion complexes with NCD and ENCD, the water solubility of daidzein was dramatically raised from 8.31 μg/mL to 15.2 and 13.2 mg/mL at 25℃, increasing by 1800-fold and 1500-fold.
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Objective To investigate the effect and safety of photodynamic therapy (PDT) with topical aminolevulinic acid (ALA) in moderate to severe acne. Methods Seventy patients with moderate to severe acne were randomly divided into two groups, one group was treated with topical ALA-PDT for 1-3 sessions with an interval of 2 weeks, the other group received oral isotretinoin 10 mg twice a day for 6 weeks. Patients were evaluated for efficacy on week 2, 4 and 6 after the initial treatment. A 3-month follow up was performed to monitor adverse events following the end treatment. Results The total effective rate was 97.1% in ALA-PDT group after 1-3 sessions of treatment, 80.0% in the control group on week 6, and the difference was significant between the two groups (P<0.05). Acne lesions tended to recur more slightly with a longer remission period in ALA-PDT group than in the control group. A temporary and local pigmentation was observed in some patients treated with ALA-PDT, but no scar was noticed. Conclusion Topical ALA-PDT is a simple and effective treatment option for moderate to severe acne with mild side effects.
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Objective To investigate the optimal concentration and incubation time of 5-aminole-vulinic acid (ALA) in photodynamic therapy of acne vulgaris. Methods Thirty patients with facial acne vulgaris were equally divided into two groups. In group 1, ALA (10%)cream was applied to acne lesions and protoporphyrin Ⅸ (PpⅨ) fluorescence was examined visually and spectroscopically at 1, 2, 3, 4 and 5 hours. In group 2, ALA cream of 3%, 5% and 10% was applied to lesions in the right cheek, left cheek, and forehead, respectively, of the same patient and incubated for 3 hours followed by photodynamie diagnosis and quantification of fluorescence intensity; clinical outcome and side effects were analyzed. Results Strong brick red PpⅨ fluorescence was observed in inflammatory papules, pustules, and cysts alter applica-tion of 10% ALA cream and irradiation with excitation light. The relative intensity of Ppix fluorescence was 1.3, 4.3, 5.1 and 5.8 in comedones, inflammatory papules, pustules and cysts, respectively, and it increased with the severity of lesions. A higher intensity of PpⅨ fluorescence was noted in patients with longer incu-bation period (3, 4 or 5 hours) compared with those with shorter incubation period (1 or 2 hours), and the difference was significant (P < 0.05). However, there was no significant difference in PpⅨ fluorescence intensity among lesions receiving ALA of different concentrations (P > 0.05). The overall clearance rate was 73% (11/15) after two courses of ALA-photodynamic therapy (PDT) in group 2. Side effects mainly included mild to moderate erythema, swelling and little exudation (occasionally). A transient pigmentation was observed in 2 patients. Neither ulceration nor scarring was noted. Conclusions ALA-PDT is suitable for the manage-ment of acne vulgaris mainly characterized by inflammatory papules, pustules and cysts. The results strongly suggest that 3% and 3 hours are the optimal concentration and incubation time of ALA in PDT of acne vulgaris.
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Objective To evaluate the usefulness of protoporphyrin Ⅸ (PpIX) fluorescence diagnosis after topical application of 5-aminolevulinic acid (ALA) in human papillomavirus (HPV) related diseases.Methods Photodynamic diagnosis (PDD) was conducted in 36 patients clinically diagnosed as genital condylomata acuminata. PpIX fluorescence was observed 2 hours following the application of 5-aminole-vulinic acid 20% cream on the lesions and subclinical lesions of these patients. Biopsy samples were resected from the lesions, subclinical lesions, and normal skin area (0.5 cm and 2 cm around the lesions) of the patients,and subjected to histopathological examination and microarray analysis for HPV DNA. Acetowhitening test was also performed at the four skin areas. Results Of the 36 patients, 30 were diagnosed as condylomata acuminata, 5 as bowenoid papulosis, and 1 as keratosis seborrheica by histopathological examination.Brick-red fluorescence of PpIX was observed in both lesions and subclinical lesions of all patients with condylomata acuminata and those with bowenoid papulosis, in subclinical lesions of 28 patients, at the area 0.5 cm around the lesions of 17 patients, and at the area 2 cm around the lesions of 5 patients. Acetowhitening and HPV DNA were also positive in lesions and subclinical lesions of patients with condylomata acuminata and those with bowenoid papulosis. Mucosa, inflammatory infiltration area and erosion tissue were prone to develop nonspecific PpIX fluorescence. Conclusions ALA-PpIX-mediated PDD can be used for the diag-nosis of clinical and subclinical HPV infection, as well as 'the location of latent HPV infection, however, it'snot recommended to be used in mucosa, inflammatory infiltration area or erosion tissue.