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Let-7 is one of the most widely studied in miRNAs at present. let-7 can inhibit cell proliferation, promote cell differentiation and apoptosis, etc. Reduced expression of let-7 in different human tumor tissues or cells is accompanied by the changes of its target genes expression, which suggests that let-7 is closely linked to cancer.
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OBJECTIVE To investigate the HCV infection and the distribution condition of HCV subtype in maintenance hemodialysis patients.METHODS A total of 210 cases with maintenance hemodialysis were recruited into this study.Serum samples were tested for anti-HCV antibodies using ELISA and HCV RNA by RT-PCR.At the same time,samples with anti-HCV IgM positive were identified for their subtype.RESULTS In all cases,91 cases(43.3%) were anti-HCV IgM positive,87 cases(41.4%) were anti-HCV IgG positive,and 105 cases(50.0%) were HCV-RNA positive.Eighty one cases(38.6%) were positive for all HCV infection markers,and 117 cases(55.7%) were positive for at least one marker.Compared that of cases with negative all HCV infection markers,the levels of ALT,AST,LDH and ?-GT in maintenance hemodialysis patients whose at least one marker was positive were significantly higher.Of 91 cases with positive anti-HCV IgM,55 cases(64.4%) were with type 1,9 cases(9.8%) with type 2,13 cases(14.2%) with type 3,and 7 cases(7.6%) with type 6.In addition,3 cases(3.2%) with types 1+6,and 4 cases(4.3%) were with types 1+3.CONCLUSIONS The infectious ratio of HCV in maintenance hemodialysis patients is high,particularly that of type 1 HCV is the highest.
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Objective To investigate the relationship between platelet-derived growth factor(PDGF)and granulocyte colony-stimulating factor(G-CSF)and psoriasis vulgaris.Methods Sera were taken from60patients with psoriasis vulgaris and42healthy controls.The serum levels of PDGF and G-CSF were measured by a dual antibody sandwich enzyme-linked immunosorbent assay(ELISA).Clinical severity of psoriasis vul-garis was assessed by psoriasis area and severity index(PASI)score.Results The serum PDGF levels were significantly higher in patients with psoriasis vulgaris than those in normal controls(P
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Objective To investigate the serum levels of hepatocyte growth factor (HGF) and granulocyte macrophage-colony stimulating factor (GM-CSF) in patients with psoriasis. Methods Serum samples were collected from 68 patients with psoriasis vulgaris and 42 healthy controls. The serum concentrations of HGF and GM-CSF were measured by a dual antibody sandwich enzyme-linked immunosorbent assay (ELISA). Clinical severity of psoriasis vulgaris was assessed by psoriasis area and severity index (PASI) score. Results Serum concentration of HGF of patients with psoriasis vulgaris in progressive stage (653.35 ? 109.26 pg/mL) was significantly higher than that of the normal controls (353.85 ? 162.63 pg/mL) (P 0.05). The serum concentration of GM-CSF was significantly higher in the patients with psoriasis vulgaris of progressive stage (115.95 ? 25.72 pg/mL) than that in the patients of stable stage (68.28 ? 24.22 pg/mL) (P