ABSTRACT
High-risk Human papilloma virus (HR-HPV) has been identified as a necessary factor for the development of precancerous lesions and invasive carcinoma of the genital tract,among which cervical cancer is the most common cancer in the female genital tract.The molecular biological mechanism of HPV leading to malignant transformation of cervix and the epidemiological information of HPV provide us with many strategies for early detection and early intervention of cervical lesions.In recent years,the incidence and mortality of cervical cancer in our country had the trend of increasing.This article reviews the research progress of HPV and cervical cancer and precancerous lesion.
ABSTRACT
High-risk Human papilloma virus (HR-HPV) has been identified as a necessary factor for the development of precancerous lesions and invasive carcinoma of the genital tract,among which cervical cancer is the most common cancer in the female genital tract.The molecular biological mechanism of HPV leading to malignant transformation of cervix and the epidemiological information of HPV provide us with many strategies for early detection and early intervention of cervical lesions.In recent years,the incidence and mortality of cervical cancer in our country had the trend of increasing.This article reviews the research progress of HPV and cervical cancer and precancerous lesion.
ABSTRACT
Objective To investigate the effect of neoadjuvant chemotherapy on the prognosis of patients with cervical cancer.Methods A systematic review of the literature about neoadjuvant chemotherapy and radical surgery was performed with searching Pubmed,Cochrane library,Medline,and Embase database from January 1990 to January 2015.According to the inclusion and exclusion criteria,the data were extracted and analyzed by Revman 5.3 system software Meta.Results Ten controlled clinical studies were concluded,including 1 543 patients (667 in preoperative neoadjuvant chemotherapy group and 876 in radical surgery).The extracted data were comparable.Meta-analysis results displayed that significant difference existed in five-year disease-free survival,node-positive rate,vascular invasion rate,and parametrial infiltration rate.It seemed that the preoperative neoadjuvant chemotherapy was prior to the radical surgery in those items.There was no significant difference between the preoperative neoadjuvant chemotherapy and radical surgery in five year survival,intraoperative complication,the positive surgical margin rate,and five-year survival rates among different chemotherapy peers (P ＞ 0.05).Conclusions For locally advanced cervical cancer patients,neoadjuvant chemotherapy can reduce the incidence of high-risk pathology,but had no significant effect on the long-term survival of patients.