ABSTRACT
OBJECTIVE:To probe into the drug categories causing high incidence of exfoliative dermatitis,and to explore the methods for the prevention and cure of this disease.METHODS:240 exfoliative dermatitis cases publicly reported in domestic journal between 1998 and 2008 were reviewed retrospectively and analyzed statistically.RESULTS:Among the total 240 cases,144 were male vs.96 female,which was chiefly induced via oral and intravenous routes;a total of 19 drugs categories(133 kinds)were involved,dominating the first 3 places were anti-infective drugs,central nervous system drugs and antipodagric drugs.Allopurinol,carbamazepine and phenobarbital were top three drugs among all kinds of drugs inducing exfoliative dermatitis.15 patients(6.25%)died.Exfoliative dermatitis was chiefly treated using stosstherapy in which a large dose of the corticosteroids combined antihistamine drugs and calcium gluconate were used,meanwhile antibiotic drugs was used as an anti-infective therapy to reduce the death secondary to septicemia.CONCLUSION:It is urgent to tighten monitoring on the use of key drugs in clinical practice to avoid and decrease the incidence of exfoliative dermatitis induced by anti-infective drugs.