ABSTRACT
Objective To investigate the effect of transcranial direct current stimulation (tDCS) on aphasia recovery after stroke. Meth-ods From April, 2012 to January, 2013, 20 aphasic patients after stroke were enrolled in an A-B experiment design. During phase A, ten times of sham tDCS and language training (five days a week) were implemented, then ten times language training combined with tDCS (five days a week) were implemented in phase B. The treatment lasted for four weeks. Picture naming was measured for all patients before and af-ter treatment both in phase A and phase B. Results The D-value scores of picture naming before and after treatment were significantly more in phase B than in phase A in both treatment items and non-treatment items (t>3.030, P<0.05). Conclusion tDCS could raise the accuracy of picture naming in patients with aphasia after stroke.
ABSTRACT
BACKGROUND:In sports or in daily life, damage due to sudden power, especialy due to non-physiological release,is commonly seen. For example, during basketbal, soccer, rugby, or martial arts movement, oppositional and explosive movements result in a higher incidence of ankle injuries. While conventional methods can improvesymptoms, the long-term efficacy is unsatisfactory, accompanied by a higher incidence of complications that are likely to cause secondary damage. OBJECTIVE:To prepare a calcified biomimetic scaffold for bone tissue engineering and to observe the therapeutic effect of this scaffold onmartialarts-induced ankle injuries. METHODS:Eighty patients withmartialarts-induced ankle injury were selected from Chengdu Sport Institute between December 2014 and December 2015. These patients were randomly assigned to control group with drug treatment and biomimetic scaffold group with calcified biomimetic scaffold implantation (n=40 per group). Acelular suspension prepared by goat cartilage was used to make cartilage tissue blocks with a calcified layer with a diameter of 8 mm in a prechiled abrasive apparatus. Then, the calcified biomimetic scaffold for bone tissue engineering was prepared using lyophilization and chemical crosslinking methods. RESULTS AND CONCLUSION:Osteochondral tissues were partialy hyalinized on the surface with the presence of osteochondral calcified layer. The hyalinized cartilage was white in color, the calcified layer existed between normal osteochondral tissues, and the subchondral bone was considered as the cancelous bone. Then the calcified layer was stained using hematoxylin-eosin. We found that cartilage cels in the calcified layer were basicaly removed, forming “empty nests” one by one. But the structure of bone cartilage in the tissue block, the calcified layer and the subchondral bone retained wel. For pain assessment, visual analog scale scores were detected and showed no difference between two groups prior to treatment (P> 0.05), but became significantly higher in the biomimetic scaffold than the control group at 1 and 4 weeks after treatment (P< 0.05). Besides, the biomimetic scaffold exhibited better therapeutic efficacy than the drug treatment (P< 0.05). Overal, this study successfuly prepare the calcified biomimetic scaffold for bone tissue engineering that is suitablefor repair of sport-induced ankle injuries.