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Objective@#To compare the chest computed tomography (CT) images of patients with acute respiratory distress syndrome (ARDS) and acute cardiogenic pulmonary edema (ACPE).@*Methods@#30 cases of patients with ARDS and 30 cases of patients with ACPE from August 2016 to August 2018 were randomly selected. All patients underwent thoracic CT examination. The distributions of grinded glass density shadow (GGO) in the lungs and changes of extrapulmonary structure were statistically analyzed.@*Results@#The differences of distributions of GGO in the upper lobe, middle lobe, lower lobe and diffuse distribution between patients with ARDS and ACPE were not significant [16.7%(5/30), 0, 16.7%(5/30), 66.7%(20/30) vs 20.0%(6/30), 0, 20.0%(6/30), 60.0%(18/30), P>0.05]. The distributions of GGO in center lung [13.3%(4/30)] was significantly lower than patients with ACPE [46.7%(14/30)] (P<0.05), while the uniform distribution rate [76.7%(23/30)] was significantly higher than patients with ACPE [46.7%(14/30)] (P<0.05), but distribution of GGO in the right side, left side, bilateral even in peripheral distribution of GGO in lung between patients with ARDS and ACPE were not significant [10.0%(3/30), 6.7%(2/30), 16.7%(5/30), 23.3%(7/30), 60.0%(18/30) vs 23.3%(7/30), 16.7%(5/30) and 60.0%(18/30), P>0.05]. The small boundary opacity of patients with ARDS [76.7%(23/30)] was significantly higher than patients with ACPE [26.7%(8/30)] (P<0.05), while the bronchial blood bundle thickening, pulmonary vascular shadow thickening, cardiac shadow enlargement, pericardial effusion were significantly lower than patients with ACPE [33.3% (10/30), 16.7%(5/30), 30.0%(9/30), 23.3%(7/30) vs 23.3%(7/30), 100.0%(30/30), 70.0%(21/30), 73.3%(22/30), 53.3%(16/30), P<0.05].@*Conclusions@#The chest CT images of patients with ARDS and ACPE are different, mainly manifestated in small boundary opacity, bronchial blood bundle thickening, pulmonary vascular opacity, cardiac opacity, pericardial effusion.
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EGFR tyrosine kinase inhibitor (EGFR-TKI) has been used successfully in clinic for the treatment of solid tumors. In the present study, we reported the discovery of from our in-house diverse compound library, which was validated to be a potent and selective EGFR-TKI. showed excellent inhibitory activities against EGFR (IC = 0.81 nmol/L), EGFR (IC = 1.2 nmol/L) and EGFR (IC = 1.1 nmol/L), but was less effective or even inactive against other nine kinases. also displayed excellent antiproliferative activities against a panel of human cancer cell lines, and exhibited the ability to reduce colony formation and wound healing the same as gefitinib. We found that upon oral administration showed better anti-tumor activity in A431 bearing xenograft mouse models compared to gefitinib. In addition, showed better intestinal absorption than gefitinib and had favorable pharmacokinetic properties and microsomal metabolic stability in different species. These studies indicate that has strong antitumor activity and , and could be used for the development of anti-lung cancer agent targeting EGFR.
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Objective To compare the chest computed tomography (CT) images of patients with acute respiratory distress syndrome (ARDS) and acute cardiogenic pulmonary edema (ACPE).Methods 30 cases of patients with ARDS and 30 cases of patients with ACPE from August 2016 to August 2018 were randomly selected.All patients underwent thoracic CT examination.The distributions of grinded glass density shadow (GGO) in the lungs and changes of extrapulmonary structure were statistically analyzed.Results The differences of distributions of GGO in the upper lobe,middle lobe,lower lobe and diffuse distribution between patients with ARDS and ACPE were not significant [16.7％ (5/30),0,16.7％ (5/30),66.7％ (20/30) vs 20.0％ (6/30),0,20.0％ (6/30),60.0％ (18/30),P ＞0.05].The distributions of GGO in center lung [13.3％ (4/30)] was significantly lower than patients with ACPE [46.7％ (14/30)] (P ＜0.05),while the uniform distribution rate [76.7％ (23/30)] was significantly higher than patients with ACPE [46.7％ (14/30)] (P ＜ 0.05),but distribution of GGO in the right side,left side,bilateral even in peripheral distribution of GGO in lung between patients with ARDS and ACPE were not significant [10.0％ (3/30),6.7％ (2/30),16.7％ (5/30),23.3％ (7/30),60.0％ (18/30) vs 23.3％ (7/30),16.7％ (5/30) and 60.0％ (18/30),P ＞ 0.05].The small boundary opacity of patients with ARDS [76.7％ (23/30)] was significantly higher than patients with ACPE [26.7％ (8/30)] (P ＜ 0.05),while the bronchial blood bundle thickening,pulmonary vascular shadow thickening,cardiac shadow enlargement,pericardial effusion were significantly lower than patients with ACPE [33.3％ (10/30),16.7％ (5/30),30.0％ (9/30),23.3％ (7/30) vs 23.3％ (7/30),100.0％ (30/30),70.0％ (21/30),73.3％ (22/30),53.3％ (16/30),P ＜0.05].Conclusions The chest CT images of patients with ARDS and ACPE are different,mainly manifestated in small boundary opacity,bronchial blood bundle thickening,pulmonary vascular opacity,cardiac opacity,pericardial effusion.
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<p><b>OBJECTIVE</b>The objective of this study is to investigate the position change of hyoid bone in obstructive sleep apnea and hypopnea syndrome (OSAHS) induced by oral appliance (OA) of double-pull rods and analyze relevant factors, subsequently investigate treatment mechanism of OA for OSAHS.</p><p><b>METHODS</b>Nine OSAHS patients (male), confirmed by polysomnography and excessive daytime sleepiness, were treated with OA of double-pull rods. After a 3-months treatment period, CT scan and three-dimensional reconstruction were made to each patient in central relation with and without OA respectively. The volume of upper airway and hyoid bone position were three-dimensional reconstructed and measured.</p><p><b>RESULTS</b>After treatment with OA of double-pull rods, the hyoid bone position was obviously changed in horizontal (5.90 +/- 2.27) mm and vertical position (3.31 +/- 1.82) mm, the volume of upper airway was enlarged (32.36 +/-14.58)%. deltaH-C3hor and deltaH-C3ver were positively related to deltavolume% (r = 0.77, P < 0.05; r = 0.79, P < 0.05), negatively related to FH-MP (r = -0.83, P < 0.05; r = -0.76, P < 0.05).</p><p><b>CONCLUSION</b>The hyoid bone position significantly change after using OA of double-pull rods. Patients with smaller FH-MP have larger horizontal change of hyoid bone.</p>