Epidemiological characteristics and spatial-temporal clustering analysis on pulmonary tuberculosis in Changsha from 2013 to 2016 / 中南大学学报(医学版)

To analyze the epidemic characteristics and to explore the spatial-temporal clusters of pulmonary tuberculosis (PTB) in Changsha from 2013 to 2016.
 Methods: Descriptive analysis and space-time permutation scan statistic were used to analyze the reported PTB cases in Changsha from 2013 to 2016.
 Results: Between 2013 and 2016, a total of 17 721 PTB cases were reported in Changsha, with annual reported incidence rate at 60.87 per 100 000 population. Males and individuals aged 15 to <60 years accounted for higher proportion of PTB cases compared to females and other age groups. The number of reported PTB cases reached peak from March to May in each year. The space-time permutation scan statistic identified one most likely cluster and two secondary clusters of PTB cases. The most likely cluster covered most areas of Liuyang City and the North-east part of Changsha County from October 1, 2013 to February 28, 2014. The first cluster occupied 12 towns (streets) in Kaifu District and Changsha County in December 2016. The second cluster included four towns (streets) in Yuhua District and Tianxin District from March 1 to September 30, in 2013.
 Conclusion: Between 2013 and 2016, significant space-time clusters of PTB cases were identified in Changsha. These findings could provide a guide for development of regional intervention strategies for PTB control.

Item selection for perinatal maternal health literacy scale / 中南大学学报(医学版)

OBJECTIVE@#To establish a more reliable and accurate scale of perinatal maternal health literacy during perinatal period by selecting items form existing scale.@*METHODS@#Two rounds of inquiry were performed by 14 experts on mother and children to evaluate the necessary and importance of 56 items by Delphi method, in which 50 items were retained. Th en we proceeded a cross-sectional survey in 350 woman who just gave birth 1-3 days before. 10% of them were selected to retest aft er 1 week. Based on these data, we used 6 different methods to select items and kept those that could pass by at least 3 different methods. The methods used in data analysis were Chi-square test, correlation coefficient method (2 kinds), factor analysis, Cronbach α coefficient method and the retest reliability method.@*RESULTS@#The Person correlation coefficient was 0.507 (P=0.004). By using the 6 statistical methods, we deleted 9 items through Chi-square test, 25 items through correlation coefficient method 1, 1 item through correlation coefficient method 2, 19 items through Cronbach α coefficient method, 8 items through factor analysis and 37 items through retest reliability method. In the end, 33 items were retained for the novel scale of maternal health literacy during perinatal period.@*CONCLUSION@#Simplified novel scale is acquired, which need to do large efforts before extensive use, such as large sample survey, reliability and validity test.

COMT genetic variation and clinical response to antipsychotic drug treatment: A Meta-analysis / 中南大学学报(医学版)

OBJECTIVE@#To examine the relationship between COMT polymorphisms and the response to antipsychotic drugs, and then provide a basis for personalized medicine of antipsychotic drugs.
@*METHODS@#We performed a systematic search from PubMed, Embase, Cochrane Library, CBM, CNKI, VIP and Wanfang database for eligible studies. Stata 12.0 was used for Meta-analysis after evaluating the quality of studies and collecting the data.
@*RESULTS@#Nine studies included 868 participants met inclusion criteria. Significant association was found between the COMT Val108/158Met gene polymorphism and antipsychotic drug efficacy. Evaluating the therapeutic efficacy through general symptoms: Met vs Val, RR=1.18, 95% CI: 1.04-1.35, P=0.013; Met/Met vs Val/Val, RR=1.40, 95% CI: 1.08-1.82, P=0.010. Evaluating the therapeutic efficacy through negative symptoms: Met vs Val, RR=1.24, 95% CI: 1.05-1.46, P=0.013; Met/Met vs Val/Val, RR=1.60, 95% CI: 1.04-2.46, P=0.031.
@*CONCLUSION@#COMT Val108/158Met gene polymorphism is significantly associated with antipsychotic drug efficacy, and Met gene is a dominant gene which displays a better response to antipsychotic drugs.

Weighted TOPSIS method and weighted RSR method in the construction of drug supervision and supply networks in rural areas of Hunan / 中南大学学报(医学版)

OBJECTIVE@#To evaluate the rationality and validity of weighted TOPSIS method and weighted RSR method to evaluate drug supervision and supply networks construction in rural areas of Hunan .@*METHODS@#Data of drug network construction in rural Hunan in 2010 were used to establish a comprehensive evaluation model, and weighted TOPSIS and RSR method were applied to this model and the results of which were compared to that of synthetical scored method to examine the validity.@*RESULTS@#A comprehensive evaluation model was established, comprising of 3 primary indices, 8 secondary indices and 56 tertiary ones. The result of weighted RSR method was highly correlated to that of synthetical scored method, yet the result of TOPSIS was less correlated to the formers. All correlations were significant (P<0.01).@*CONCLUSION@#Both weighted RSR and TOPSIS are not perfect methods, but the application of the methods in drug network evaluation is scientific and effective.

Label identities and basic situation of health food in Changsha / 中南大学学报(医学版)

OBJECTIVE@#To study the relevant information on the label of health food in Changsha, and provide scientific evidence for health food hygienic supervision.@*METHODS@#Investigation was conducted in department stores, supermarkets, pharmacies, and wholesale markets in the 5 districts in Changsha with multistage stratified sampling method. Self designed basic information of health food questionnaire was used to investigate the quality of labels the health food products.@*RESULTS@#Among the 408 random samples, the unidentified rates of label items were ranked in descending order: functional components (49.8%), unsuited community (27.9%), manufacturing date (23.0%), approval number and others (9.6%). The qualified rates of labels were different in different management types (χ(2)=59.793, P<0.05): the highest rate was in supermarkets (71.15%), followed by pharmacies (70.07%), shopping malls (57.47%), and wholesale markets (26.23%).@*CONCLUSION@#The supervision of label identities of health food should be strengthened, especially for the health food in the wholesale markets.

A comprehensive evaluation of the health services in Hunan Province / 中南大学学报(医学版)

OBJECTIVE@#To establish a comprehensive evaluation system for the development of health services, and to assess the levels of health services in 2008 and 2009 in Hunan compared with seven other provinces in central China, so as to provide a basis for hygiene management decisions.@*METHODS@#In order to establish a comprehensive evaluation system, a Delphi method, a boundary value method, and an RSR method were applied, respectively, to survey indices of health service development, to screen indices, and to determine index weights. A weighted TOPSIS method was used to evaluate the development status of health services of the eight provinces.@*RESULTS@#The Cronbach's alpha coefficient of the questionnaire was 0.884, indicating a proper surface validity and a content validity. The expert positive coefficient, authority coefficient and Kendall coefficient were 93.75%, 0.8117, and 0.31, respectively. A comprehensive evaluation system, which consisted of 3 primary indices, 10 secondary indices and 52 tertiary indices, was established. The result of the comprehensive evaluation showed that the health services development of Hunan Province ranked 7th and 6th among the 8 central provinces for 2008 and 2009, respectively.@*CONCLUSION@#The established, comprehensive evaluation system has a high reliability. Health services development of Hunan Province is relatively backward among the 8 central provinces.

Nutrition and food safety and influence factors for lower grade pupils in 2 counties in West China / 中南大学学报(医学版)

OBJECTIVE@#To explore the knowledge of, attitude to and practice in nutrition and food safety, the influence factors, and to provide reference for relevant health education programs.@*METHODS@#A total of 510 randomly selected students from Grade 1 to 3 randomly selected were surveyed by a nutrition and food safety questionnaire in Huize of Yunnan Province and Zhen'an of Shaanxi Province. Multiple-linear regression was used to analyze the influence factors of nutrition and food safety.@*RESULTS@#The correct answer rate on nutrition and food safety knowledge of the pupils from Grade 1 to 3 was 74.4%. Nutrition and food safety knowledge score was 11.16±2.51, but only 7.8% of the students correctly answered "How much water should we drink every day". Students who agreed that it is necessary to learn nutrition and food safety knowledge in school accounted for 78.6% and 73.9%, respectively. At least half of the students showed correct behaviors in 7 aspects. The students who ate beans and meat daily or regularly accounted for 28.4% and 34.9%, but only 9.2% of the students drank more than 7 cups of water daily. The multiple-linear regression showed that the major influence factors were the area, grade, status of lodge and singleton.@*CONCLUSION@#Education is needed for students to form better dietary habits, especially those in low grades, non-singleton, and in board schools.

Prediction and Forecast of Nosocomial Infection Risk Factor / 中国医师杂志

Objective To study the main influence factors of nosocomial infection(NI) and establish a model to predict and forecast the risk of NI on patients in hospitals. Methods Clinical data of 27352 inpatients extracted from hospital information system were sorted out and coded, and a logistic regression model about the probability of NI was established. The risk of NI was divided into four scales. Results With multiple factor analysis,16 risk factors of NI were identified, which were age, high body temperature, numbers of diagnosis, days of staying in hospital and seriousness, numbers of routine test for urine, times of blood transfusion, use or without use of antibiotic and radiotherapy, turning over the bodies or not, relationships between infection and interventional operations, with or without diabetes, categories of diseases based on ICD-9, numbers of interventional operations, type of anesthesia and department of admission. If NI was judged when predicted probability(Pr)of logistic regression model exceeded 0 35, the specificity and false diagnostic rate of diagnostic test were 0 995 and 0 005 respectively, and the area under ROC curve was 0 986. According to decision tree method, the risk of NI was classified into four degrees: low (Pr