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1.
Article in Chinese | WPRIM | ID: wpr-1005268

ABSTRACT

In western medicine, the small intestine anatomically belongs to the digestive system and is also an important immune organ of the body. The innate immune system of the small intestine consists of a tissue barrier, innate immune cells, and innate immune molecules. The dysfunction of any part can cause metabolic disorders and eventually lead to diabetes. In the pathogenesis of diabetes, traditional Chinese medicine (TCM) has the theory of ''spleen deficiency causing diabetes'', which points out that the impaired spleen function results in inadequate transformation, impaired essence spread, and turbidity by essence accumulation, which is the core pathological link of blood glucose metabolism disorder in diabetes. In terms of the relationship between the small intestine and the spleen, the theory of TCM holds that the small intestine is located in the abdomen and the abdomen is dominated by the spleen. The digestion, absorption, and endocrine functions of the small intestine are also similar to the functions of spleen in governing movement and transformation and spreading essence by virtue of spleen Qi. Therefore, the anatomical and physiological functions of the small intestine in western medicine are closely related to the spleen in TCM. At the same time, the spleen is closely related to the innate immune function of the small intestine in TCM. The spleen participates in the generation and distribution of defense Qi, and the process of defense Qi playing the external function is similar to the process of the activation of the innate immune response. The spleen is also an important organ involved in fluid metabolism, which can cooperate with the lung and kidney to timely remove turbid fluid from the body. It can also work with the stomach as the hub of Qi ascending and descending and regulate the physiological activities of "clear Yang" and "turbid Yin", so as to ensure the homeostasis of the internal environment of the body, which is the basis for maintaining the normal function of the innate immunity of the small intestine. Therefore, taking "spleen deficiency causing diabetes" as a bridge, the theory of TCM and western medicine were combined to explain the relationship between small intestinal innate immunity imbalance and the pathogenesis of diabetes from the perspective of TCM, which is helpful to understand the pathogenesis of diabetes in a deeper level and also provide a new perspective and new way for the prevention and treatment of this disease with TCM.

2.
Chinese Journal of Immunology ; (12): 2638-2645, 2023.
Article in Chinese | WPRIM | ID: wpr-1024702

ABSTRACT

Diabetes mellitus(DM),as a common and frequently-occurring disease,has become a huge burden of chronic diseases worldwide,whose pathogenesis is very complex and has not yet been fully elucidated.Small intestine is one of important immune organ in body,and relationship between its innate immune function and DM has become forefront of research in medical field.In this paper,role of intestinal innate immunity in pathogenesis of DM is reviewed,including tissue barrier dysfunction of small intestine,dysfunction of intestinal innate immune cells and imbalance of proportion of intestinal innate immune molecules,in order to provide references for future research on related mechanisms.

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