ABSTRACT
Objective: To report the percentage of non-vaccine pneumococcal serotypes and theirantibiotic susceptibility pattern in children with invasive peumococcal disease. Methods:Invasive pneumococcal isolates of children <5 years during January 2007 to December2016 were serotyped by a co-agglutination reaction and sequential multiplex polymerasechain reaction. Results: Among the total 170 S. pneumoniae invasiveisolates, 54 (31.8%)and 44 (25.9 %) were the serotypes, which are not included in current 10-valent or 13-valent vaccines, respectively. Very low resistance was observed against penicillin (4.5%)and all isolates were susceptible to cefotaxime. Conclusions: One-fourth to one-third ofthe S. pneumoniae serotypes in under-five children with invasive pneumococcal diseaseare not covered by existing pneumococcal vaccines in India.