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Objective To analyze the characteristics of changes in serum cholesterol level in sepsis patients,and to explore its correlation with prognosis.Methods A retrospective analysis was conducted.Two hundred and six patients with sepsis admitted in the Third People's Hospital of Dalian from February 2015 to February 2019 were enrolled (observation group),and 206 patients without sepsis hospitalized in the same period were served as control group.The basic clinical data of the two groups were collected,and the results of total cholesterol (TC),low density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol (HDL-C) and biochemical parameters were compared.The patients with sepsis were divided into death group and survival group,and risk factors influencing the prognosis of patients with sepsis were analyzed with Logistic regression analysis.Results Compared with control group,the levels of serum TC [(2.49 ± 1.14) mmoFL vs.(3.40 ± 1.26) mmoFL,t =6.240] and HDL-C [(1.66 ± 0.89) mmol/L vs.(2.49 ± 0.81) mmol/L,t =5.532] in observation group were significantly lower (P ＜ 0.05),and that of LDL-C showed no statistically significant difference [(1.96 ± 0.91) mmol/L vs.(2.10 ± 0.72) mmo/L,t =0.940,P＞0.05].In observation group,the patients in death group (85 cases)were older than those of the survival group (121 cases)[(75.6 ± 8.6) years vs.(62.5 ± 6.0) years,t =4.565],serum creatinine (SCr) was higher than that of survival group [(246.2 ± 34.6) μmol/L vs.(165.4 ± 35.6)μ mol/L,t =5.420],and the levels of serum TC [(2.15 ± 0.59) mmol/L vs.(2.89 ± 1.02) mmol/L,t =5.475],HDL-C [(1.40 ± 0.42) mmol/L vs.(1.94 ± 0.52) mmol/L,t =4.856] and LDL-C [(1.73 ± 0.56)mmol/L vs.(1.97 ± 0.72) mmol/L,t =4.261] were significantly lower than those of survival group (P＜0.05).Logistic regression analysis showed that age was the risk factor of death in sepsis patients (OR =1.256,95％ CI 1.006-1.056,P=0.012),and TC was the protective factor for the prognosis of sepsispatients (OR =-0.758,95％CI 0.579-0.867,P =0.014).Conclusions The levels of TC,HDL-C in sepsis patients are significantly lowered,and the levels of TC,HDL-C,LDL-C in death group are significantly lower than those in survival group.TC may be used as a clinical indicator to assess the outcome of sepsis patients.
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Objective@#To analyze the characteristics of changes in serum cholesterol level in sepsis patients, and to explore its correlation with prognosis.@*Methods@#A retrospective analysis was conducted. Two hundred and six patients with sepsis admitted in the Third People′s Hospital of Dalian from February 2015 to February 2019 were enrolled (observation group), and 206 patients without sepsis hospitalized in the same period were served as control group. The basic clinical data of the two groups were collected, and the results of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and biochemical parameters were compared. The patients with sepsis were divided into death group and survival group, and risk factors influencing the prognosis of patients with sepsis were analyzed with Logistic regression analysis.@*Results@#Compared with control group, the levels of serum TC [(2.49 ± 1.14) mmol/L vs. (3.40 ± 1.26) mmol/L, t=6.240] and HDL-C [(1.66 ± 0.89) mmol/L vs. (2.49 ± 0.81) mmol/L, t=5.532] in observation group were significantly lower (P<0.05), and that of LDL-C showed no statistically significant difference [(1.96 ± 0.91) mmol/L vs. (2.10 ± 0.72) mmo/L, t=0.940, P>0.05]. In observation group, the patients in death group (85 cases) were older than those of the survival group (121 cases)[(75.6 ± 8.6) years vs. (62.5 ± 6.0) years, t=4.565], serum creatinine (SCr) was higher than that of survival group [(246.2 ± 34.6) μmol/L vs. (165.4 ± 35.6) μmol/L, t=5.420], and the levels of serum TC [(2.15 ± 0.59) mmol/L vs. (2.89 ± 1.02) mmol/L, t= 5.475], HDL-C [(1.40 ± 0.42) mmol/L vs. (1.94 ± 0.52) mmol/L, t=4.856] and LDL-C [(1.73 ± 0.56) mmol/L vs. (1.97 ± 0.72) mmol/L, t=4.261] were significantly lower than those of survival group (P<0.05). Logistic regression analysis showed that age was the risk factor of death in sepsis patients (OR=1.256, 95% CI 1.006 -1.056, P=0.012), and TC was the protective factor for the prognosis of sepsispatients (OR=-0.758, 95%CI 0.579-0.867, P=0.014).@*Conclusions@#The levels of TC, HDL-C in sepsis patients are significantly lowered, and the levels of TC, HDL-C, LDL-C in death group are significantly lower than those in survival group. TC may be used as a clinical indicator to assess the outcome of sepsis patients.
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Objective To investigate the relationship between brachial- ankle pulse wave velocity (baPWV) and heart rate variability (HRV), cardiac function in patients with essential hypertension.Methods One hundred and eighty patients with essential hypertensive from January 2014 to August 2016 were collected.The patients were divided into elevated group(baPWV≥1 400 cm/s,100 cases) and normal group (baPWV < 1 400 cm/s, 80 cases) according to the baPWV value. The general data, heart function and HRV of the 2 groups were compared. Results The standard deviation of all normal-to-normal(SDNN),standard deviation of all 5-min mean NN intervals(SDANN)and proportion of number of pairs of adjacent normal-to-normal intervals by more than 50 ms(PNN50%)in elevated group were significantly lower than those in normal group: (116.3 ± 17.0) ms vs. (135.8 ± 19.4) ms, (96.0 ± 21.4) ms vs. (120.0 ± 25.1) ms and (9.3 ± 3.1)% vs. (12.0 ± 4.1)%,and there were statistical differences (P<0.01); there was no statistical difference in root mean square of successive differences (RMSSD)between 2 groups(P>0.05);the left ventricular ejection fraction(LVEF)in elevated group was significantly lower than that in normal group:(57.2 ± 7.0)% vs.(63.0 ± 8.2)%,and there was statistical difference (P<0.01); there were no statistical differences in left ventricular end-diastolic dimension (LVDd) and left ventricular end systolic dimension (LVSd) between 2 groups (P>0.05); the interventricular septal thickness (IVST) in elevated group was significantly higher than that in normal group:(11.4 ± 2.5)mm vs.(9.5 ± 1.4)mm,and there was statistical difference(P<0.01).In patients with essential hypertension,there was a significant negative correlation between baPWV and SDNN,SDANN, PNN50%,LVEF(P<0.01),and there was a significant positive correlation between baPWV and IVST (P<0.05).Conclusions The baPWV measured in patients with essential hypertension can effectively reflect the HRV and cardiac function of the patients.