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Objective:To evaluate the value of synthetic MRI combined with DWI in the diagnosis of benign and malignant breast lesions.Methods:The data of 184 consecutive patients with suspected breast lesions in Yunnan Cancer Hospital from July to September 2019 were prospectively analyzed. All patients were randomly assigned to training group ( n=110) and validation group ( n=74), and underwent conventional MRI and synthetic MRI respectively before and after contrast injection. At the maximum slice of the lesion, the ROI was drawn along the edge and recorded as "tumor". In the solid area with the most obvious tumor enhancement, the second ROI was drawn and recorded as "local". At the same time, ADC values (ADC local and ADC tumor) and relaxation time values (T local and T tumor) were measured. T and T + represented the relaxation time value of the ROI pre-and post-contrast scanning. ΔT% represented the relative change rate in T value between pre-and post-contrast scanning.The rank sum test was used to test the quantitative parameters of benign and malignant breast lesions in the training group and the validation group, and the variables with P<0.05 were included in the binary logistic regression analysis to screen the independent variables and establish the prediction model. The area under ROC curve was used to evaluate the discrimination of parameters and models. The clinical applicability of model was analyzed by decision curve analysis (DCA). Results:In the training group, univariate analysis showed that there were significant differences in T 1tumor, T 1+tumor, ΔT 1% tumor, T 2local, T 2+local, T 2tumor and T 2+tumor, ADC local, ADC tumor between benign and malignant breast lesions ( P<0.05). Multivariate logistic regression analysis showed that T 1+tumor, ΔT 1% tumor, T 2tumor, ADC local, ADC tumor were independent variables in the diagnosis of breast cancer. The relaxation time model (model A: T 1+tumor, ΔT 1% tumor, T 2tumor) and ADC model (model B: ADC local, ADC tumor) established by combining the above variables had the same diagnostic efficiency (AUC=0.905, 0.914, Z=-1.874, P=0.062), and the multi-parameter combination model (model C: T 1+tumor, ΔT 1% tumor, T 2tumor, ADC local, ADC tumor) had the highest diagnostic efficiency (AUC=0.965). DCA analysis showed that when the threshold probability ranges between 21%-99% (training cohort) and 15%-99% (validation cohort), the net benefit of model C was better than model A and B. Conclusion:The multi-parameter combined prediction model established based on the relaxation time value and ADC can identify breast cancer efficiently and can be used as an auxiliary diagnostic tool.
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Objective To observed the changes of plasma levels of NT‐proBNP and hs‐CRP in patients with different types of coronary heart disease and investigate its clinical value .Methods 156 patients with CHD diagnosed by coronary computed tomo‐graphy angiography(CTA) were enrolled in this study ,including 35 cases of acute myocardial infarction(AMI) ,63 cases of unstable angina(UAP) and 58 cases of stable angina(SAP) .And 61 persons without CHD were selected as the control(CTR) .Plasma levels of NT‐proBNP and hs‐CRP were detected by the methods of immmunofluorescent antibody technic reader and turbidimetry ,respec‐tively .Results Plasma NT‐proBNP levels of AMI ,UAP ,SAP and CTR group were (1 903 .99 ± 2 055 .21) ,(897 .27 ± 947 .34) , (677 .98 ± 718 .12) ,(129 .39 ± 126 .49)ng/L ,respect ively .Plasma hs‐CRP levels were (28 .47 ± 20 .49) ,(12 .68 ± 8 .64) ,(10 .56 ± 7 .17) ,(2 .82 ± 1 .23)mg/L ,respectively .Plasma levels of NT‐proBNP and hs‐CRP in AMI group were obviously higher than those in UAP ,SAP and CTR group(P0 .05) . Plasma BNP levels were positively correlated with plasma hs‐CRP .Conclusion Plasma levels of NT‐proBNP and hs‐CRP are asso‐ciated with different clinical phenotyes of CHD .Those markers may be helpful to the risk stratification and prognosis of CHD .
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<p><b>OBJECTIVE</b>To study the effects of Cynomorium songaricum polysaccharide (CSP) on telomere length in blood and brain tissues of aged mice in order to provide some evidence for CSP's development and applying in the clinical uses.</p><p><b>METHOD</b>Kunming mice were intraperitoneal injected D-galactose (500 mg x kg(-1) x d(-1)) to make the aging models, and different dosages of CSP (20, 40, 80 mg x kg(-1)) were given by gavage for 56 days. The average length of telomere was determined by real-time fluorescence quantitative PCR.</p><p><b>RESULT</b>The relative T/S ratio of the group high and middle dosages of CSP in blood were 1.64 +/- 0.36 and 1.33 +/0.28, respectively, and higher than that of the group of senescence 1.01 +/- 0.13 (P < 0.01). Values of the group of high, middle, and low dosages of CSP in brain tissues were 3.34 +/- 0.58, 2.30 +/- 0. 75 and 1.55 +/- 0.58, respectively, and significantly higher than that of the group of senescence 1.04 +/- 0.33 (P < 0.01).</p><p><b>CONCLUSION</b>CSP can exert the anti-aging effects by increase telomere length f senescence mice.</p>