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Objective@#To investigate the prevalence of video display terminal syndrome (VDT) among medical students in university, and to explore the correlation between VDT syndrome and depressive symptoms, so as to provide theoretical guidance for promoting college students mental health.@*Methods@#A total of 3 265 freshmen and juniors in the Department of Medicine of Nanchang University were surveyed with census method in November 2019 to collect information regarding general information, symptoms related to VDT syndrome, depression status.@*Results@#In the valid questionnaire, the detection rate of VDT syndrome among college students was 33.3%, and the detection rates of VDT syndrome varied significantly by sex and clinical major( χ 2=6.45, 18.82 , P <0.05); The detection rate of depressive symptoms was 54.6%. One way ANOVA showed that there was significant differences in VDT syndrome status between those with and without depression symptoms ( χ 2=63.88, P < 0.01 ). Multivariate Logistic regression showed that VDT syndrome could increase the risk of detecting depression ( OR=1.84, 95%CI=1.58-2.14, P <0.01).@*Conclusion@#VDT syndrome has a high detection rate in college medical students and is a risk factor for depression in medical students. Society and schools should pay attention to health education on the rational use of video terminals for medical students, and take corresponding measures to intervene, so as to improve the physical and mental health of medical students.
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·AIM: To compare and analyze the clinical efficacy of different artificial tears for patients with xerophthalmia after phacoemulsification.·METHODS:Retrospective analysis on the clinical data of 150 cases (150 eyes) treated by phacoemulsification in our hospital from March 2014 to April 2017. And according to the artificial tears used, they were divided into Group A ( control group) and B ( application of sodium hyaluronate eye drops) , Group C ( used carbomer gel eye drops) ,50 cases 50 eyes in every group. We compared and analyzed the BUT, FL, SⅠt findings, OSDI scores preoperatively and 1wk, 1 and 3mo postoperatively, and visual acuity before and 3mo after operation in the three groups.·RESULTS:There were no differences in BUT, FL, SⅠt and OSDI scores between the three groups before and at 1wk after the operation (P>0. 05). At 1mo after operation, the levels of BUT and SⅠt in Group B and Group C were higher than those in Group A, and the scores of OSDI and FL were lower than those in Group A (P<0. 05); between Group B and Group C there was no difference in BUT, FL, SⅠt levels and OSDI score (P>0. 05). After 3mo, the levels of BUT and SⅠt in the Group B and Group C were higher than that in the Group A, and the FL level and OSDI score were lower than those in the Group A ( P<0. 05);the levels of BUT and SⅠt in the Group C were higher than those in the Group B, and the FL level and the OSDI score were lower than those in the Group B ( P<0. 05 ) . The visual acuity of the three groups was improved at 3mo after the operation (P<0. 05), and there was no difference in LogMAR visual acuity between the three groups before and 3mo after operation (P>0. 05).· CONCLUSION: different types of artificial tear can improve the symptoms of dry eyes in patients age-related cataract after phacoemulsification, in which carbomer eye drops or lipid containing artificial tears improve postoperative dry eye symptoms and signs, and will not affect the recovery of visual acuity.
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AIM:To investigate the combination therapeutic effect of Ginkgobalide B (GKB) and retinal stem cells (RSCs)transplantation on glaucoma in rats.METHODS:Rats were divided randomly into five groups:control group,glaucoma group,RSCs group,GKB group and RSCs combination therapy group.A chronic glaucoma model was established in rats,accordingly.The morphological changes in ocular tissues were analyzed by HE staining.Retinal ganglion cells apoptosis were analyzed by TUNEL staining.The protein expressions of Bcl-2,Bax,Cleaved caspase-3 and Cleaved caspase-9 were determined by Western blot.The mRNA levels of Bcl-2 and Bax were determined by qPCR.RESULTS:HE staining revealed that RSCs transplantation or GKB treatment decreased fiber interstitial edema and vacuole,as compared to glaucoma group.Furthermore,this improvement was more pronounced in combination therapy group than in single treatment alone.Combination therapy significantly inhibited retinal ganglion cells apoptosis,increased Bcl-2 mRNA and protein expression,but decreased Bax mRNA and protein expression.Moreover,the protein expression of Cleaved caspase-3 and Cleaved caspase-9 expression were decreased after combination therapy.CONCLUSION:Our data demonstrate that combination of Ginkgobalide B and retinal stem cells transplantation can inhibit retinal ganglion cells apoptosis and protect against glaucoma.These effects may be associated with the regulation of Bcl-2,Bax,Cleaved caspase-3 and Cleaved caspase-9 expression.