ABSTRACT
BACKGROUND: Polyetheretherketone (PEEK) and Its composites have a unique set of properties, and 3D printing technology can customize personalized Implants according to the patient's condition, and the effective combination of the two plays a significant role In the field of bone repair. OBJECTIVE: To summarize the application status of PEEK and Its composite combined with 3D printing technology In the field of bone repair, and to further predict the application prospects of the effective combination of the two. METHODS: CNKI, PubMed, and Web of Science databases were retrieved with the search terms “PEEK, PEEK composites, bone defect repair, PEEK Implants, PEEK 3D printing, prosthodontlcs” in English and Chinese, respectively, for the articles published from April 1995 to April 2019. Totally 147 articles were searched, and finally 51 eligible articles were enrolled for review in accordance with the inclusion and exclusion criteria. RESULTS AND CONCLUSION: Biologically active materials and the particles or fibers with Improved mechanical properties were Introduced Into the PEEK matrix to prepare its composite. 3D printing technology was used to precisely customize Implants that are highly matched to the patient's defect. The Implants with good biocompatibility, bioactlvity, and mechanical properties exhibited good therapeutic effects In the repair of skull, jaw, spine, lumbar vertebra, artificial joint and oral defects. They Improved patient satisfaction after treatment. This article summarized the application of PEEK, its composite and 3D printing technology In the repair of various bone defects, and expressed its views on the application and prospect of personalized PEEK implants or prostheses prepared with 3D printing technology.
ABSTRACT
Objective To study mechanical properties of the bone scaffold with different structure and its internal flow field distributions,so as to provide a direct comparison and judgment on model structure and offer an effective guidance for bone scaffold structure design.Methods Bone scaffold with natural,woven and spherical pore structure were reconstructed respectively by using Pro/Engineer and Mimics.The effective elastic modulus for three kinds of scaffolds,as well as their stress distributions and internal flow field distributions under three-dimensional perfusion culture system were analyzed with the finite element method.Results The bone scaffold with natural structure showed smaller effective elastic modulus,smaller peak stress and more uniform stress distributions under the same pressure.With the same initial velocity and fluid viscosity,the bone scaffold with natural structure showed smaller internal velocity,wall shear stress and wall pressure.Conclusions The bone scaffold with natural structure has better biomechanical properties,which corresponds to the design criteria of bone scaffold in bone tissue engineering.