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Objective:To evaluate the efficacy of modular flexible ureteroscopy combined with minimally invasive percutaneous nephrolithotomy in patients with complex kidney stones.Methods:From March 2017 to February 2019 in Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Hebei Province, 150 patients with complex kidney stones were selected. The patients were divided into group A, group B and group C by sortition method with 50 cases each. Group A was treated with modular flexible ureteroscopy, group B was treated with standard percutaneous nephrolithotomy, and group C was treated with modular flexible ureteroscopy combined with minimally invasive percutaneous nephrolithotomy. The operation time, transoperative bleeding, hospitalization time, calculi clearance 1- and 3-month after operation, procalcitonin (PCT) and C-reactive protein (CRP) 2 h before operation and 1 and 3 d after operation were compared among 3 groups.Results:The operation time, transoperative bleeding and hospitalization time in group C were significantly lower than those in group A and group B: (65.25 ± 7.90) min vs. (99.73 ± 8.52) and (96.11 ± 9.92) min, (33.22 ± 3.70) ml vs. (41.54 ± 3.62) and (45.17 ± 3.30) ml, (3.90 ± 0.90) d vs. (4.77 ± 1.17) and (5.70 ± 1.19) d, the calculi clearance 1- and 3-month after operation was significantly higher than that in group A and group B: 94.00% (47/50) vs. 80.00% (40/50) and 82.00% (41/50), 98.00% (49/50) vs. 84.00% (42/50) and 86.00% (43/50), and there were statistical differences ( P<0.05). There were no statistical differences in PCT and CRP 2 h before operation among 3 groups ( P>0.05); the PCT and CRP 1 and 3 d after operation in group C were significantly lower than those in group A and group B, and there were statistical differences ( P<0.05). There were no statistical differences in all indexes between group A and group B ( P>0.05). Conclusions:Modular flexible ureteroscopy combined with minimally invasive percutaneous nephrolithotomy can effectively improve calculi clearance, reduce surgical trauma, shorten operation time, promote recovery, and have significant therapeutic effects in the treatment of complex kidney stones.
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Objective:To explore the effect of solution-focused brief therapy (SFBT) on negative emotions such as anxiety and depression in patients with ulcerative colitis.Methods:From April 2018 to December 2019, a total of 160 patients with ulcerative colitis who met inclusion criteria were randomly divided into a control group and an experimental group and underwent psychological interventions. We employed conventional psychological interventions for the control group and solution-focused brief therapy for the experimental group. The Hamilton Anxiety Scale (HAMA) and the Hamilton Depression Scale (HAMD) were used to evaluate post-intervention effects.Results:Before intervention, there were no statistically significant differences in patient demographics, treatment plans, anxiety scores, or depression scores between the two groups of patients. After intervention, the HAMA score of the experimental group was (10.91±8.96) points, which was statistically significantly lower than the control group (12.73±7.98) points ( t value was 5.099, P<0.05). The HAMD score of the patients in the experimental group was (12.02±9.21) points, which was statistically significantly lower than the control group (14.85±8.91) points ( t value was 4.856, P<0.05). Conclusion:Solution-focused brief therapy may be a better approach than traditional psychological intervention methods to manage anxiety, depression, and other negative emotions in patients with ulcerative colitis.
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Researches on gene sequencing find that long non-coding RNA (lncRNA)does not encode protein, however,it participates in the biological pathway of gastric cancer and plays a certain role in the process of prognosis and outcome of gastric cancer. With the generation of gene databases and the popularity of computer algorithms,the researches on the prognosis-related lncRNA of gastric cancer are gradually increasing. The bioinformatics study of prognosis-related lncRNA of gastric cancer can provide ideas for experimental researches. It is expected to provide evidence for the diagnosis and treatment of gastric cancer and improve prognosis by exploring more lncRNAs that are related to the prognosis of gastric cancer.
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Objective To understand the real experience of male patients with gynecomastia before and after breast endoscopic surgery,and to provide evidence for the development of perioperative nursing strategies.Methods A qualitative phenomenological study was conducted to conduct in-depth interviews with 14 male patients undergoing endoscopic mastectomy.Results Fourteen male patients with gynecomastia were interviewed during the course of treatment and during the perioperative period of endoscopic surgery.Four themes were summarized:(1) self-image disorder (inferiority complex,sensitive psychology,dissatisfaction with body shape);(2) anxiety and confusion about the disease before surgery;(3) desire to obtain professional knowledge from medical staff.(4) cognitive differences in the treatment of breast endoscopic surgery (repeated worries about the disease,improvement of health-related cognitive ability).Conclusions Gynecomastia patients with low self-esteem,sensitive psychological status and lack of knowledge of breast endoscopic surgery may lead to anxiety,depression and other psychological problems,seriously affecting their physical health.In order to provide theoretical basis for the nursing of gynecomastia patients under endoscopy,the holistic rehabilitation of heart should update nursing strategy and improve the service mode.
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Objective To clarify the relationship between endocrine treatment compliance and medication beliefs of estrogen receptor-positive (ER +) breast cancer patients. Methods Totally 219 patients who were diagnosed as breast cancer and received endocrine therapy in a tertiary hospital were investigated using general condition questionnaire, Morisky Medication Adherence Scale, Beliefs about Medicine Questionnaire(BMQ)by means of face to face,telephone,WeChat.Data analysis was conducted by SPSS 19.0. Results The score of universal beliefs for ER+breast cancer patients was(13.38±5.35) points.The score of the necessary perception was(9.98±4.69)points.The score of the adverse effects of medication was (5.35 ± 2.67) points. The drug compliance score was (5.82 ± 2.15) points.The correlation coefficient of the medication beliefs and the endocrine treatment compliance was 0.578.The Pearson correlation coefficient of each dimension and the total questionnaire was 0.411 to 0.456. Conclusions For ER+breast cancer patients, the higher the medication beliefs is, the better the endocrine treatment compliance is.So it is provided an insight that nurses should enhance the ER +breast cancer patients′medication beliefs in order to get a better and longer survival life.
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Objective To investigate the effect of self efficacy and coronary heart disease knowledge on health literacy of young and middle-aged patients with coronary heart disease.Methods Investigation was conducted among 500 patients using general questionnaire,chronic health literacy scale,self-efficacy scale and coronary heart disease knowledge questionnaire.Results The score of health literacy for young and middle-aged patients was (97.76± 15.45),and 57％ of the patients had good health literacy.Self-efficacy and coronary heart disease knowledge were positively correlated with health literacy (r=0.301,r=0.309;P＜ 0.05).Multiple regression analysis showed that self-efficacy (β=0.210),coronary heart disease knowledge (β=0.226) were significant factors of health literacy(both P＜0.01).Conclusion The self-efficacy and coronary heart disease knowledge have impact on the health literacy.The more self-efficacy and coronary heart disease knowledge,the higher health literacy.
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Breast cancer is one of the most common cancers in China. With increasing of the incidence and mortality, the harm to women is becoming much serious. Estrogen positive patients need to take 5-10 years′ endocrine drugs to prolong survival and prevent recurrence. Endocrine therapy has become one of the most common and effective methods in the treatment of breast cancer. In order to achieve the desired effect of cancer treatment, reduce cancer metastasis and recurrence rate, good compliance is essential. In conclusion, this review summarizes the evaluation of compliance, various evaluation tools and their use.
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Objective To examine the status quo and relationships between medication adherence and beliefs regarding endocrine therapy in breast cancer patients.Methods A total of 273 patients were recruited from one tertiary hospital in Shenyang by convenience sampling method.They were investigated by using the Morisky medication adherence scale and brief medication questionnaire (BMQ) for medication adherence and behefs about medicines.Results The mean 8-item medication adherence scale score was 6.39 ± 1.68,with 65％ medication compliance,which was lower than the domestic and foreign literature levels.The mean BMQ score was-0.02 ± 4.394 points,given that the conviction was low.Medication beliefs in medication compliance impact strength was statistically significant (r =0.457,P ＜ 0.05),with positive correlation.Conclusion The current status of medication adherence and beliefs regarding endocrine therapy in breast cancer patients was not satisfactory.Based on the urgent need to improve the compliance of endocrine therapy in patients with breast cancer in China,breast specialist nurses need to focus on the establishment of a nursing follow-up program for endocrine therapy to improve patient compliance.
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Objective To explore the relationship between anxiety ,resilience and hope levels among gastric cancer patients ,so as to provide evi?dence for psychological intervention. Methods Cluster sampling design was used to select 324 gastric cancer patients. The anxiety self?assess?ment scale,resilience scale and hope scale are used to measure the related indicators. Results The comparative analysis showed that patients with different genders,education levels and marital status had different scores in anxiety level and resilience level(P<0.05),and those with differ?ent genders and marital status got different hope levels(P<0.05). Correlation analysis showed that anxiety was negatively correlated with resil?ience and hope levels(P<0.05),the coefficient of correlations ranged from-0.556 to-0.124. Multiple linear regression analysis showed that edu?cation level,marital status,income level,resilience,hope levels explained portion of the variance of anxiety. Conclusion Clinical nursing staff should reduce the gastric cancer patients′anxiety by improving their resilience and hope levels.
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@#Objective To explore the relationship between the cardiovascular health behavior and health factor and the executive function in newly acute cerebral infarction patients. Methods Wisconsin Card Sorting Test (WCST) and Clock Drawing Task (CDT) were used to evaluate the executive function of 1440 patients with newly acute cerebral infarction, with 240 cases in each subgroup respectively in 0-1,2, 3, 4, 5, 6 component ideal cardiovascular health behavior and health factor. The impact of ideal cardiovascular health behaviors and factors on the executive function was analyzed combined with the general clinical data. Results The incurrence rates of executive function impairment in cerebral infarction patient with 0-1, 2, 3, 4, 5, 6 component ideal cardiovascular health behavior and health factor were 90.8%,85%, 66.7%, 42.5%, 20.8%, 13.4% respectively; compared with the patients with 0-1 of cardiovascular health behavior and health factors,the scores of WCST significantly changed in the patients with 2, 3, 4, 5, 6 component ideal cardiovascular health behavior and health factor (P<0.05).There was no significant difference in gender and infarction location among 6 groups (P>0.05), but was in age, ducation degree,infarction size and complications (P<0.05). After adjusting the age, infarction size, infarction location and complications, multivariate logistic regression analysis showed that compared with the patients with 0-1 of cardiovascular health behavior and health factors, 2, 3, 4, 5, 6 component ideal cardiovascular health behavior and health factors were protective factors for the executive dysfunction of cerebral infarction patients, the OR were 0.686, 0.564, 0.369, 0.232, 0.116 respectively. Conclusion The cardiovascular health behavior and health factor protect the executive function in new acute cerebral infarction.
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Objective To study the effects of integrative body-mind training with cognitive rehabilitation based on the sensory integration training theory on executive function and anxiety and depression mood in patients with traumatic brain injury.Methods 85 cases were randomly divided into the control group (42 cases) and the treatment group (43 cases).The control group took targeted cognitive rehabilitation with sensory integration training theory and the treatment group was given targeted integrative bodymind training based on this training.Before training and after 3 months,the cognitive function and executive function were detected by the Behavioral Assessment of Dysexecutive Syndrome (BADS); the cognitive dysfunction were evaluated by Loewenstein Occupation Therapy Cognitive Assessment (LOTCA); Anxiety and Depression were evaluated by Self-rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS).Results There was no marked differences in BADS,LOTCA,SDS and SAS scores before treatment; Compared with the control group,they were much improved after training; Moreover,they were much more improved in the treatment group than those of the control group.Conclusions Integrative bodymind training with cognitive rehabilitation based on the sensory integration training theory can improve the executive function and regulate the mood on cognitive dysfunction in patients with traumatic brain injury.
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Objective To study the effects of self-management of knee osteoarthritis (KOA) on the function and quality of life in old pa-tients. Methods From October 2011 to April 2012, 100 patients with KOA from 2 communities in Tangshan, Hebei were recruited, and were as control group and intervention group based on the community. The intervention group learned a KOA self-management course, which consisted of 6 classes of 1.5 to 2 hours, once a week, taught by health professionals. The control group read the KOA self-management hand-book only. They were measured with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Arthritis Impact Measurement Scale 2nd version-Short Form (AIMS2-SF) before and 6 months after intervention. Results The score of WOMAC and AIMS2-SF improved more in the intervention group than in the control group (P<0.05). Conclusion The KOA self-management program is effective on function and quality of life in old patients with KOA in community.
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Objective To explore the effects of SB203580(a MAPK inhibitor) on the expression of Homer1a in hippocampus and learning-memory after diffuse brain injury in rats.Method Male Sprague-Dawlley rats were divided randomly into three groups:control group,diffuse brain injury(DBI) group and DBI+ SB203580 group (peritoneal injection,0.01 μg/kg).Morphological changes of neuronal cells were observed by electron microscope and the expression of Homer1a and phosphorylated p38MAPK was detected by immunohistochemistry and learning and memory functions were performed with Morris water maze (MWM).Results Compared with control group,ultrastructure of neuronal cells and synapses were significantly.The levels of phosphorylated p38MAPK(76.98±16.64,2.28±0.40,P＜0.05) and Homer1a (62.96± 12.74,1.28±0.10,P＜0.05)respectively were increased after injury impaired.MWM test showed that the escaping latency was prolonged((74.64± 8.96)s,(24.96±4.98)s,P＜0.05) and the frequency of crossing the platform was decreased(4.48± 1.12,12.65±2.36,P＜0.05).Compared with the model group,SB203580 decreased ultrastructure impariment in neuronal cells and synapses and decreased phosphorylated p38MAPK expression(54.82± 12.48,76.98± 16.64,P＜0.05) and increased Homer1a expression(54.82 ±12.48,76.98± 16.64,P＜0.05).MWM test showed that the escaping latency was shorten ((46.72±6.58) s,(74.64± 8.96) s,P＜0.05),and the frequency of crossing the platform was increased (7.56± 1.20,4.48± 1.12,P＜0.05).Conclusion SB203580 improves the learning-memory recovery after DBI,which is related to inhibition of p38MAPK activation and increasing Homer1a expression.
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Objective To investigate the effects of inhibitors U0126 on expression of ERK1/2 and Ku70 in the hippocampus in diabetic rat after global cerebral ischemia and reperfusion.Methods The global cerebral ischemia model of diabetic rat was made by streptozotocin-induction with four-vessel occlusion of modified Pulsinelli' s method.Adult male SD rats (n =80) were randomly (random number) divided into 4 groups (n =20 rats per group),namely sham operation (SO) group,normoglycemia ischemia/reperfusion (NI/R) group,diabetes cerebral ischemia (DCI) group and DCI + U0126 (0.01 mg/kg Ⅳ)group.The morphological changes of neuronal cells were observed by using HE staining 1 h,6 h,24 h and 48 h after I/R; and immunohistochemistry method was used to detect the levels of phosphorylated ERK1/2 and Ku70 protein.Statistical analysis of experimental data was carried out by using SPSS 17.0 software.Comparisons between groups were done by using factorial variance analysis,and difference was statistically significant at P ＜ 0.05.Results Compared with SO group,some neurons showed histopathologic changes of neuronal necrosis and apoptosis in NI/R group as well as the phosphorylated ERK1/2 levels increased at 1,6,24,48 h (P ＜ 0.05) ; The Ku70 levels increased at 1,6 h (P ＜ 0.05) and were lower at 24 h,48 h (P ＜ 0.05) ; Compared with the NI/R group,the histopathological changes of brain tissue was more severe in DCI group,and the phosphorylated ERK1/2 levels were lower at 1,6,24,48 h (P ＜ 0.05) ;The Ku70 protein levels were lower at 1,6,24,48 h in DCI group (P ＜ 0.05) ; Compared with DCI group,the histopathological changes of neuronal necrosis and apoptosis was more severe in DCI + U0126 group; and the phosphorylated ERK1/2 expressions respectively decreased at 1,6,24,48 h (P ＜0.05) ;and the Ku70 protein levels were lower at 1,6,24,48 h (P ＜ 0.05).Conclusions U0126 enhanced the damage of nerve cells by inhibiting the activation of ERK1/2,thereby reducing the level of Ku70 protein in brain hippocampus of diabetic rats after global cerebral ischemia.