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Objective:To explore the diagnostic value of preoperative serum C-reactive protein(CRP) and thyroid stimulating hormone(TSH) levels in subacute thyroiditis, so as to provide evidence for reducing clinical mistreatment.Methods:From May 2011 to January 2020, the clinical data of 3 525 cases who received thyroid nodule surgery in the First Affiliated Hospital of Anhui University of Science & Technology were retrospectively analyzed.According to the results of pathology, the patients were classified as subacute thyroiditis group, chronic lymphocytic thyroiditis group, thyroid cancer group and benign thyroid nodule group.Fifty-six cases of subacute thyroiditis group(group A) and 56 cases of Hashimoto thyroiditis group(group B) were selected to meet the conditions of the group.Fifty-six cases of thyroid cancer group(group C) and 56 cases of benign thyroid nodule group(group D) were selected according to the random number table method.The serum levels of CRP, TSH and other indicators of each group were counted and analyzed before operation.Results:The misdiagnosis rate of subacute thyroiditis was 1.7%.CRP level in group A was significantly higher than that in groups B, C and D( Z=-3.024, -6.449, -6.012, all P<0.01). The TSH level in group A was significantly lower than that in groups B, C and D( Z=-2.397, -3.877, -2.583, P=0.017, 0.000 and 0.010), while that in group C was significantly higher than group D( Z=-2.421, P=0.016). The area under ROC curve for CRP diagnosis of subacute thyroiditis was 84.3%(95% CI: 0.770-0.917), when the optimal cutoff value was 3.62 mg/L, the diagnostic sensitivity and specificity were 69% and 87%, respectively. Conclusion:Familiarity with clinical manifestations and preoperative serum CRP and TSH levels as differential indicators of benign and malignant thyroid nodules can reduce misdiagnosis of subacute thyroiditis.
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Objective:To explore the clinical curative effect of nifedipine controlled-release tablets combined with telmisartan on diabetes mellitus combined with hypertension and their influences on serum homocysteine (Hcy) and C-reactive protein (CRP).Methods:Eighty-four patients with diabetes mellitus and hypertension who were admitted to Huainan First People′s Hospital from February 2016 to November 2019 were enrolled. They were divided into combination group and control group by random number table method, with 42 cases in each group. The control group was treated with nifedipine controlled-release tablets, while combination group was additionally treated with telmisartan. Both groups were continuously treated for 4 weeks. After treatment, clinical curative effect in both groups was evaluated. The levels of diastolic blood pressure (DBP), systolic blood pressure (SBP), fasting plasma glucose (FPG), 2 h postprandial blood glucose (2 hPG), glycosylated hemoglobin (HbA 1c), total cholesterol (TC), triacylglycerol (TG), Hcy and CRP were measured before and after treatment. The number of cases with adverse reactions was recorded. Results:After treatment, total response rate in combination group was significantly higher than that in control group [92.24%(40/42) vs. 80.95%(34/42)] ( P<0.05). After treatment, there were no significant differences in FPG, 2 hPG and HbA 1c between the two groups ( P>0.05). After treatment, the levels of SBP, DBP, TC, TG, CRP and Hcy in combination group were significantly lower than those in control group [(132.64 ± 7.53) mmHg)(1 mmHg=0.133 kPa) vs. (142.81 ± 4.63) mmHg, (79.63 ± 6.84) mmHg vs.(85.71 ± 5.86) mmHg, (4.87 ± 0.61) mmol/L vs. (5.14 ± 0.62) mmol/L, (1.57 ± 0.41) mmol/L vs.(1.76 ± 0.45) mmol/L,(8.76 ± 1.53) mg/L vs. (9.51 ± 1.86) mg/L, (12.52 ± 1.97) μmol/L vs.(13.48 ± 2.36) μmol/L]( P<0.05). During treatment period, there was no significant difference in incidence of adverse reactions between combination group and control group [16.67% (7/42) vs. 19.05%(8/42)]( P>0.05). Conclusions:The clinical curative effect of nifedipine controlled-release tablets combined with telmisartan is good on diabetes mellitus combined with hypertension, which can regulate blood pressure, blood lipids, Hcy and CRP levels, and relieve disease progression, with good safety.
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AIM: To determine whether Jiunaoning injection has protective effects on oxygen/glucose-deprived and reperfusion injury-induced neurons. METHODS: Various concentrations of Jiunaoning injection (0.5-5 mL/L) were used to observe their effects on cultured rat cortical neurons induced by oxygen/glucose-deprived and reperfusion injury in various time points. The neuronal metabolic rate and viability were assessed by using 3-(4,5-dimethylthiazol)-2, 5-diphenyl-tetra zoliumbromide (MTT) and lactate dehydrogenase (LDH) assay. RESULTS: Jiunaoning injection enhanced the neuronal metabolic rate in a dose-dependent manner in the range from 0.5 to 5 mL/L, and Jiunaoning injection (1.5-2.5 mL/L) enhanced the neuronal metabolic rate, decreased the cell death rate and depressed LDH leak rate significantly. CONCLUSION: Jiunaoning injection has an affirmative protective effect on oxygen/glucose-deprived and reperfusion-induced neuronal injury.