ABSTRACT
Objective To investigate the incidence and influence factors of chronic complications of inpa-tients with type 2 diabetes mellitus(T2DM)and to provide reference for the comprehensive prevention and treat-ment. Methods A retrospective analysis was conducted to analyze the occurrence and development of chronic complications of T2DM hospitalized patients in a third-level first-class hospital of Ningxia from January to Decem-ber in 2015.Results All of the 739 T2DM patients,the total incidence of chronic complications was 74.6%.The top five chronic diseases were large vessel disease,renal disease,retinopathy,peripheral vascular disease and neuropathy. Multivariate logistic regression analysis showed that the duration of disease(OR = 1.004,95% CI:1.002~1.006)and occupation(taking workers as controls,farmers' OR =3.122,95% CI:1.420~6.861,unem-ployed persons' OR=2.771,95% CI:1.389~5.527)were the independent risk factors of chronic complications of T2DM.Conclusions The total incidence of chronic complications of T2DM is high.We should strengthen the com-prehensive intervention of controllable risk factors for reducing the incidence of complications,decreasing medical costs and enhancing overall quality of life of patients.
ABSTRACT
Objective To establish methods for the determination of spinosin and total saponins in compound Zaoshen tablet .Methods The separation of spinosin was performed on Agilent Zorbax SB C18 column (250 mm × 4 .6 mm ,5 μm) at 30℃ with water and acetonitrile as mobile phase for gradient elution at the flow rate of 1 .0 ml/min .The detection wavelength was 335 nm .Determination of total saponins was fulfilled by column chromatography followed by UV spectrometer with vanil-lin glacial acetic acid colorimetry .The detection wavelength was 560 nm .Results Linear range of spinosin was 20-100 μg/ml (r=0 .9990) and total saponins was 40-200 μg/ml (r=1 .0000) .The average recoveries for accuracy tests were 99 .55% and 99 .85% respectively .Conclusion Those methods are accurate and reliable .They can be used for the quality control of com-pound Zaoshen tablet .