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Braz. j. med. biol. res ; 41(7): 634-639, July 2008. tab
Article in English | LILACS | ID: lil-489524

ABSTRACT

The type of fluid used during resuscitation may have an important impact on tissue edema. We evaluated the impact of two different regimens of fluid resuscitation on hemodynamics and on lung and intestinal edema during splanchnic hypoperfusion in rabbits. The study included 16 female New Zealand rabbits (2.9 to 3.3 kg body weight, aged 8 to 12 months) with splanchnic ischemia induced by ligation of the superior mesenteric artery. The animals were randomized into two experimental groups: group I (N = 9) received 12 mL·kg-1·h-1 lactated Ringer solution and 20 mL/kg 6 percent hydroxyethyl starch solution; group II (N = 7) received 36 mL·kg-1·h-1 lactated Ringer solution and 20 mL/kg 0.9 percent saline. A segment from the ileum was isolated to be perfused. A tonometric catheter was placed in a second gut segment. Superior mesenteric artery (Q SMA) and aortic (Qaorta) flows were measured using ultrasonic flow probes. After 4 h of fluid resuscitation, tissue specimens were immediately removed for estimations of gut and lung edema. There were no differences in global and regional perfusion variables, lung wet-to-dry weight ratios and oxygenation indices between groups. Gut wet-to-dry weight ratio was significantly lower in the crystalloid/colloid-treated group (4.9 ± 1.5) than in the crystalloid-treated group (7.3 ± 2.4) (P < 0.05). In this model of intestinal ischemia, fluid resuscitation with crystalloids caused more gut edema than a combination of crystalloids and colloids.


Subject(s)
Animals , Female , Rabbits , Edema/etiology , Hydroxyethyl Starch Derivatives/administration & dosage , Ischemia/therapy , Isotonic Solutions/administration & dosage , Mesenteric Vascular Occlusion/therapy , Resuscitation/methods , Disease Models, Animal , Edema/pathology , Hydroxyethyl Starch Derivatives/adverse effects , Intestinal Diseases/etiology , Intestinal Diseases/pathology , Intestinal Mucosa/blood supply , Intestinal Mucosa/pathology , Ischemia/pathology , Isotonic Solutions/adverse effects , Lung Diseases/etiology , Lung Diseases/pathology , Mesenteric Vascular Occlusion/pathology , Random Allocation , Resuscitation/adverse effects , Severity of Illness Index , Splanchnic Circulation
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