Association between vaccination and the risk of immunoglobulin A vasculitis in children / 中国当代儿科杂志

OBJECTIVES@#To study the effect of vaccination on the short-term risk of immunoglobulin A vasculitis (IgAV) in children.@*METHODS@#A retrospective analysis was conducted on the general data and the vaccination history within one year prior to onset in children with IgAV hospitalized in the Children's Hospital Affiliated to Zhengzhou University from November 2021 to January 2023. Vaccine exposure rates in the risk period (3 months prior to IgAV onset) and the control period were compared by autocontrol-case crossover analysis, and the odds ratio and 95% confidence interval (95%CI) were calculated. A sensitivity analysis for the one-month and two-month risk periods was conducted.@*RESULTS@#A total of 193 children with IgAV were included, with a median age of 7.0 years. Among the 193 children, 36 (18.7%) received at least one dose of the vaccine within 1 year prior to IgAV onset, and 14 (7.3%) received at least one dose of the vaccine during the 3-month risk period. Compared to the unvaccinated IgAV group, the vaccinated IgAV group had a significantly younger age of onset (P<0.05). There were no significant differences in the proportions of children with gastrointestinal involvement, renal involvement, and joint involvement between the two groups (P>0.05). The odds ratio for developing IgAV after receiving any type of vaccine within 3 months prior to IgAV onset was 2.08 (95%CI: 0.82-5.27, P>0.05). Further sensitivity analysis for the 1-month and 2-month risk periods demonstrated that the odds ratios for developing IgAV after receiving any type of vaccine were 2.74 (95%CI: 0.72-10.48, P>0.05) and 2.72 (95%CI: 0.95-7.77, P>0.05), respectively.@*CONCLUSIONS@#Vaccination dose not increase the risk of IgAV, nor does it exacerbate clinical symptoms in children with IgAV.

Treatment of osteoporotic distal femur fractures with less invasive stabilizing system (LISS) and high strength injectable graft / 中国骨伤

<p><b>OBJECTIVE</b>To evaluate the clinical results of less invasive stabilizing system (LISS) and high strength injectable graft in the treatment of osteoporotic distal femur fractures.</p><p><b>METHODS</b>From Feb. 2005 to Feb. 2008, 26 cases (15 males, 11 females) of osteoporotic distal femur fractures were treated with less invasive stabilizing system (LISS) and high strength injectable graft. The mean age of the patients was 68.5 years (ranging from 59 to 81 years). According to AO classification,there were 9 cases type A3, 6 cases type C1, 7 cases type C2, 4 cases type C3.</p><p><b>RESULTS</b>The mean operation time was (110 +/- 15) min (ranging from 90 to 135 min). The patients were followed-up for from 12 to 28 months (averaged 18 months). The mean healing time was 20.5 weeks(ranging from 16.5 to 28 weeks). No deep infection, fixation loosening, breakage or failure of implants were observed after the operations. According to Rasmussen radiological evaluation,the results showed 19 cases for "excellent", 7 cases for "good". One year postoperatively, the mean ROM of the knees was 2 degrees to 125 degrees, the HSS knee score was from 59 to 99 points with average of (86.5 +/- 8.2) points. According to HSS scoring system, the results showed 22 cases for "excellent", 2 cases for "good", 1 for "fair" and 1 for "poor".</p><p><b>CONCLUSION</b>The less invasive stabilizing system (LISS) and high strength injectable graft is an effective way for the treatment of osteoporotic distal femur fractures.</p>