Epidemiological and clinical characteristics of 16 cases of gnathostomiasis / 中国人兽共患病学报

To investigate the epidemiological and clinical characteristics of emerging infectious gnathostomiasis in China,a retrospective analysis was performed on 16 cases of gnathostomiasis found during 2009-2011.Patients consisted of 11 women and 5 men.The median age was 48 years (ranging from 27 to 68years).Eleven out of 16 patients (68.8％) had history of ingesting raw or undercooked freshwater fish.The main manifestation of patients was cutaneous form.Clinical symptoms included migratory swelling,creeping eruption and skin rash.Among them,43.8％ (7/16) of patients presented eosinophilia.The results of serological tests showed all patients were Gnathostoma-specific IgG positive by dot immunogold fitration assay (DIGFA) and 5 cases (31.2 ％) were positive by immunoblot for detection of specific 24-kDa protein band reaction.The median time from onset of symptoms to diagnosis was 12 months with a range of 2 weeks to 3 years.A total of 11 patients were treated with albendazole and/or ivermectin.Ten patients did not relapse post treatment.During 2009-2011,the number of patients with gnathostomiasis significantly increased due to consumption of raw or under-cooked loaches and swamp eels.Serological test was a necessary tool to support clinical diagnosis while gnathostomiasis commonly presented complex symptoms.Ivermectin and albendazole were effective to treat gnathostomiasis.

Design and implementation of inpatient's laboratory report self-printing program used in doctor station / 医疗卫生装备

Objective To explore a new mode for self-printing by a doctor station.Methods A self-printing program was developed with Delphi 6.0,which obtained the information on the hospitalized and discharged patients from oracle database of HIS first,then inquired the examination results and printing identification in SQL database of LIS and printed the laboratory report finally.Results The new mode saved the workload for laboratory report printing and distribution,shortened the time consumed for pasting the report,reduced the ratio for missed and false pasting,avoided the pathogen transmission due to the report and increased the report quality.Conclusion The new mode realizes data sharing and raises working efficiency,and thus is worthy promoting practically.

Design and implementation of inpatient's laboratory report self-printing program used in doctor station / 医疗卫生装备

Objective To explore a new mode for self-printing by a doctor station.Methods A self-printing program was developed with Delphi 6.0,which obtained the information on the hospitalized and discharged patients from oracle database of HIS first,then inquired the examination results and printing identification in SQL database of LIS and printed the laboratory report finally.Results The new mode saved the workload for laboratory report printing and distribution,shortened the time consumed for pasting the report,reduced the ratio for missed and false pasting,avoided the pathogen transmission due to the report and increased the report quality.Conclusion The new mode realizes data sharing and raises working efficiency,and thus is worthy promoting practically.

Preparation of atenolol monolithic osmotic pump tablets / 药学学报

<p><b>AIM</b>The simplified preparative method and formulation for atenolol monolithic osmotic pump tablets were investigated.</p><p><b>METHODS</b>The core tablets with an indentation were compressed by the punch with a needle. Osmotic pump tablets were prepared by coating the indented tablets. Similarity factor was used to evaluate formulation of osmotic pump tablets.</p><p><b>RESULTS</b>The formulation of core tablets and the composition and thickness of coating membrane showed marked effects on drug release. Orifice size of core tablets in the range of 1.00 - 1.14 mm scarcely affected drug release.</p><p><b>CONCLUSION</b>The preparation of osmotic pump tablets was simplified with the exempting of laser drilling. The atenolol monolithic osmotic pump tablets could deliver drug constantly for 24 h.</p>

Sandwiched osmotic pump tablet for controlled release of water-insoluble drug / 药学学报

<p><b>AIM</b>To study sandwiched osmotic pump tablet for delivering water-insoluble drug for 24 hours.</p><p><b>METHODS</b>Sandwiched osmotic pump tablet was prepared using nifedipine as the model drug. The effects of various formulation variables and orifice size on drug release were studied. The mechanical properties of cellulose acetate membrane were also investigated.</p><p><b>RESULTS</b>Polyethylene oxide of drug layer and potassium chloride of push layer showed marked positive effects on drug release. In the range of 0.50 mm to 1.40 mm, orifice size hardly affects drug release. Cellulose acetate membrane is strong enough to assure the integrity of osmotic pump tablet and could sustain an internal pressure ranging from 0.34 MPa to 2.85 MPa.</p><p><b>CONCLUSION</b>Sandwiched osmotic pump tablet can deliver water-insoluble drug constantly for 24 hours. Release media and agitation rate scarcely affect drug release. Compared with the commercialized push-pull osmotic pump tablet, sandwiched osmotic pump tablet is easy in preparation with exempting identification of drug layer before drilling.</p>

Unitary-core osmotic pump tablet for controlled release of water-insoluble drug / 药学学报

<p><b>AIM</b>To study unitary-core osmotic pump tablet for delivering water-insoluble drug for 24 hours.</p><p><b>METHODS</b>Unitary-core osmotic pump tablet was prepared using nifedipine as the model drug. The effects of various core formulation variables on drug release were studied.</p><p><b>RESULTS</b>Polyethylene oxide and potassium chloride have comparable positive effects on drug release, whereas, nifedipine has markedly negative effect on drug release.</p><p><b>CONCLUSION</b>Unitary-core osmotic pump tablet is very easy in preparation and it can deliver water-insoluble drug in substantially constant rate for 24 hours.</p>