ABSTRACT
A partir de uma revisão histórica da medicina brasileira, enfoca a história da hematologia no mundo e no Brasil, dando destaque à hematologia no século XX e na atualidade. Apresenta, ainda, uma bibliografia hematológica brasileira
Subject(s)
Brazil , Schools, Medical/history , Hematology/education , Hematology/history , History of MedicineABSTRACT
Nineteen Brazilian HIV-infected hemophiliacs and their stable heterosexual sexual partners were studied with the aim of assessing the rate of HIV transmission in this at risk group. The mean length of relationship between couples was 7.4 years. The hemophiliac men were Class II (n=6),III (n=11) and IVa (n=2) of the CDC classification. They had decreased CD4+ and elevated CD8+ cell numbers; five had p24 antigenemia. We found 3 HIV-infected women (l5.8 percent) by routine and confirmatory tests, a prevalence similar to that seen in other countries. They were asymptomatic and had no detectable p24 antigenemia. The 3 seropositive women's partners were Class II and III-CDC, and had normal CD4+ and CD8+ values and no p24 antigenemia. All seronegative women also had normal CD4+ and CD8+ numbers, except for elevated CD8+ cells in three of them, but immune abnormalities had already been seen in some seronegative partners at high risk for HIV infection. Our results reinforce previous suggestions that heterosexual transmission to stable female partners occurs preferentially early after initiation of sexual exposure, and possibly when the transmitter has high levels of viremia and regular sexual activity.
Subject(s)
Adult , Middle Aged , Female , Humans , Adolescent , Sexual Partners , HIV Infections/transmission , Hemophilia A/complications , Blood Cell Count , Brazil , HIV Infections/immunology , Risk FactorsABSTRACT
Foram corados os mononucleares do sangue periférico de 53 doadores de sangue do hemocentro de Säo Paulo pelas técnicas de imunofluorescência e da imunoperoxidase em esfregaços. A identificaçäo dos linfócitos e dos monócitos foi feita usando-se os seguintes anticorpos monoclonais: 1- para imunofluorescência: OKT3, OKIA (Ortho Diagnostic), 2- para imunoperoxidase: Leu1, DR (Becton Dickson). Também foram usados os monoclonais anti-Igs, anti-Kappa e anti-Lambda para a marcaçäo de linfócitos pelas técnicas de imunofluorescência e de imunoperoxidase. A análise comparativa dos resultados mostra que: 1§- as médias de positividade das células linfocitárias T do sangue anti-Kappa e anti-Lambda também foram próximas, embora os coeficientes de correlaçäo dos casos (n=12) que tiveram determinaçäo concomitante tenha favorecido o valor - 0,31.3§ - Os anticorpos monoclonais que marcam mais especificamente as células monocitárias (OKIa/DR) revelaram médias maiores pela técnica da imunoperoxidase, uma vez que esta permite a identificaçäo da morfologia típica desta linhagem celular