ABSTRACT
The present work was conducted to study the effect of sesame oil [SO], rapeseeds oil [RSO] and their combinations with two levels [5and10%] on the nutritional value, percent of liver weight/body weight, lipid parameters [cholesterol, triglycerides, low-density lipoprotein- cholesterol LDL-c, very low-density lipoprotein VLDL-c] kidney function [uric acid and urea nitrogen] and liver function [aspartate amino transferase AST and alanine amino transferase ALT] of hypercholesterolemic rats. Forty-eight male albino rats were divided into two main groups, the first main group [n = 6] fed on basal diet as a negative control group. The second main group [42 rats] fed two weeks on hypercholesterolemic diet. then divided into seven subgroups as a follows: Subgroup [1] fed on hypercholesterolemic diet as a positive control group: [2] fed on hypercholesterolemic diet containing [5% sesame oil - 5% corn oil]; [3] fed on hypercholesterolemic diet containing [10% sesame oil]; [4] fed on hypercholesterolemic diet containing [5% rapeseeds oil + 5% corn oil]; [5] fed on hypercholesterolemic diet containing [10% rapeseeds oil]; [6] fed on hypercholesterolemic diet containing [2.5% sesame oil + 2.5% rapeseeds oil + 5% corn oil] and subgroup [7] fed on hypercholesterolemic diet containing [5% sesame oil + 5% rapeseeds oil]. Addition of sesame oil, rapeseeds oil and their combinations to hypercholesterolemic diets improved body weight gain%, and the percent liver weight / body weight, especially [the high levels of oils]. The mean values of serum cholesterol, triglycerides, LDL-c, VLDL-c, uric acid, urea nitrogen, AST and ALT decreased in all treated groups with [sesame oil, rapeseeds oil and their combinations], as compared to the positive control group, while HDL-c increased. It was concluded that high level of rapeseeds oil and the combinations of oils [5 and 10%] realized the best effect on lipid profile, kidney and liver functions