ABSTRACT
In neonates, bilirubin tends to be deposited in body tissues, especially the skin and mucous membranes. Jaundice is an early symptom of bilirubin excretion disorders. Therefore, the aim of this study was to investigate the effect of clofibrate on reducing neonatal jaundice. In this systematic review, international databases, including PubMed, Scopus, Web of Science, Embase, Cochrane, and Google Scholar, were searched without time and language restrictions. The reference lists of all studies ultimately included were manually searched. In the 17 articles reviewed, with a sample size of 665 people published between 2005 and 2019, the average weight of the neonates varied from 2,186 g to 4,000 g. Furthermore, the average age of neonates varied from 2 days to 9 days. Four doses of clofibrate (25, 30, 50, 100 mg/kg of neonatal body weight) were used. The bilirubin level of neonates significantly decreased in the intervention group 24, 36, 48, and 72 hours after the start of treatment. Clofibrate administration decreased total serum bilirubin, especially from the second day onwards, and also reduced hospitalization time, hospital costs, and side effects from hospitalization.
ABSTRACT
Background: Iron deficiency is often observed in obese individuals. The prevalence of obesity has increased at an epidemic rate. A few small studies have noted a possible association between iron deficiency and obesity. The purpose of the study has been determined relationship between anthropometric including body mass index and the size of abdomen and iron-shortage anemia
Materials and Methods: Descriptive, analytical, and cross sectional methods of research have been applied in the study. The instruments used to collect the data were a set of organized items in the questionnaire and a checklist contained the measurement of abdominal obesity, height, weight, BMI, the results of ferritin levels, hemoglobin, hematocrit, and TIBC and MCV. The tools were validated via content validity and test-retest. The participants were the staff [n=300] of Hamadan branch, Islamic Azad university, Iran, who were selected via census sampling technique. To analyze the data, descriptive statistics and inferential statistics, that is, chi-square, Pearson correlation coefficient, and ANOVA were run using SPSS software
Results: 48.4% had overweight and 43.9% had various degrees of general obesity. 45.7% of women and 1.9% of men suffered from abdominal obesity. 3.2% of men had ferritin levels less than 20ng/dl and 79.2% of them had high levels of TIBC, while 31.5% of women had ferritin serum less than 12ng per dl and 73.9% of them had high TIBC. There was a significant relationship between abdominal obesity and TIBC, HB, HCT, and ferritin serum [p<0.0005]
Conclusion: The results of this study indicate the high prevalence of overweight, obesity, and abdominal obesity and their relationship with iron deficiency anemia. These are non-communicable disease, which are directly related to the lifestyle