Growth, developmental, and behavioral outcomes of HIV-affected preschool children in Thailand.

In order to determine growth, developmental, and behavioral outcomes of Thai HIV-affected preschool children, a cross-sectional study was performed at Chiang Mai University Hospital. Thirty HIV-affected children aged 3 to 5 years and 35 of age-matched control with their respective caregivers participated. There was no difference in growth and behavioral outcome, as measured by a standardized Child Behavioral Checklist, between the two groups. Cognitive functioning, as measured by a Thai intellectual assessment score, was significantly lower in the HIV-affected group (p = 0.03). Twenty percent of the HIV-affected group had below average level IQ (< or = 89) compared to 11% in the control. The risk factors were low caregivers' family income and being brought up by relatives as opposed to biological parents. An early intervention program for these children should be promoted as a result.

Quality of life of children with attention-deficit/hyper activity disorder.

OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) has an impact on children and families. The purpose of this study was to assess the health-related quality of life between school-age children with ADHD compared with those without physical or mental disorders. MATERIAL AND METHOD: Self- and parent-reports describing the quality of life, covering 4 domains: physical, emotional, social, and school functioning, were obtained from 46 children with ADHD and 94 control children. At the time of the study, 17 of 46 children reported receiving medication for ADHD. RESULTS: After controlling for age and demographic background, both children with ADHD and their parents reported having a significantly lower quality of life score than controls and their parents. Children with ADHD also reported themselves to have a significantly low physical score, despite their physically healthy status. CONCLUSION: Children with ADHD had impairment of their quality of life in the physical and psychosocial domains. Improvement of health-related quality of life should be integrated in the overall planning of the treatment goals.

Primary hypomagnesemia in Thai infants: a case report with 7 years follow-up and review of literature.

A female Thai baby born to non-consanguineous parents, presented with primary hypomagnesemia at 10 weeks of age, and suffered recurrent convulsions that responded to magnesium supplementation. She was found to have hypomagnesemia (Mg 0.35-1.02 mEq/L) and a low urinary magnesium excretion of less than 10 mg per day, or urinary Mg/Cr that ranged from 0.005-0.01 mg/mg. Intermittent hypomagnesemia and one episode of hypocalcemia with occasional convulsions developed, due to irregular consumption of oral magnesium sulfate, which had a bitter taste, caused frequent loose stools and black staining of the teeth. Better compliance after switching from magnesium sulfate to magnesium oxide resulted in an increased level of serum magnesium and the gradual disappearance of the black staining of the teeth and frequent loose stools. The patient required an oral elemental magnesium dosage of 15-30 mg/kg/day to maintain the serum magnesium level at between 1.02-1.33 mEq/L and keep her free from convulsions. The follow-up period was 7 years during which the patient showed normal physical growth and a mild degree of mental retardation.

Psychosocial problems in children with thalassemia and their siblings.

Beta-thalassemia is a chronic illness causing serious symptoms to children and a burden to families. The purpose of this study was to evaluate psychosocial problems in children with thalassemia and their siblings by using a semi-structured interview and the Pediatric Symptom Checklist (PSC). The study sample included 82 children with thalassemia, 20 siblings, and 50 control children without a chronic illness. With children and families demographically controlled, psychosocial problems were significantly more common in children with thalassemia than in those without chronic illness, 28.05 per cent vs 4 per cent (p=0.001), but there was no difference between siblings and the controls, 5 per cent vs 4 per cent (p=0.64). The mean PSC score in children with thalassemia was higher than that in the sibling and control group (18.34 vs 10.95 and 10.28, respectively; p<0.001). These findings suggest an increased risk of psychosocial problems in children with thalassemia that psychosocial intervention may be required to prevent major psychiatric disorders.