ABSTRACT
Objective To explore the prognostic factors of endometrial carcinoma.Methods 166 patients with endometrial carcinoma in Cancer Hospital of Shantou University Medical College from May 1996 to June 2009 were analyzed retrospectively.Prognostic factors were analyzed by univariate analysis.Results The total 5-year survival rate of 166 cases was 86.7 ％.The univariate analysis showed that the age,deep myometrial invasion,lymph-node metastasis and operative-pathological staging were significantly associated with the prognosis (P ＜ 0.05).As well as,according to muhivariate Cox proportional-hazard model,3 independent factors as the age,deep myometrial invasion and lymph-node metastasis were related significantly to overall survival (P ＜ 0.05).Conclusions The 5-year survival rate of endometrial carcinoma is high.The age,deep myometrial invasion and lymph-node metastasis are independent prognostic factors of endometrial carcinoma.
ABSTRACT
0bjective To investigate the pattern of disease relapse and prognostic risk factor of patients with cervical carcinoma and pelvic lymph node metastasis.Methotis A total of 124 cases of International Federation of Gynecology and Obstetricfi(FIG0)I bl-Ⅱ a cervical carcinoma with pelvic node metastasis who were treated at the Cancer Center of Sun Yat-sen University during January 1994 to December 2001 were selected for this study.Prognosis and recurrence were retrospectively analyzed using the clinico.pathological data.Results The overall 5 year flun,ival and 5 year disease-free survival were 63.3% and 61.4%.respectively.Overall recurrence rate was 39.5%(49/124),among which intra-pelvic relapse (61.0%,25/41)was significantly more common than extra-pelvic relapse(31.7%,13/41;P=0.008).Multivariate analysis identified involvement of common iliac node as an independent prognostic factor(P=O.035).According to this factor,node-positive patients could be divided into low risk group(without common iliac node involvement,104 cases)and hiSh risk group(with common iliac node involvement,20 cases).The 5 year disease-free survival were 69.4%and 24.5%respectively,with a significant difference(P=0.003).Intra.pelvic relapse was observed in 22.1%(23/104)of low risk and 25.0% (5/20)of high risk group respectively,with no significant difference(P>0.05).However extra-pelvicrelapse wag seen in 7.7%(8/104)of low risk and 40.0%(8/20)of hish risk group,with a significant difference(P<0.01).Conclusions Common iliac node involvement is a significant factor influencing the prognosis of patients with cervical carcinoma and pelvic lymph node metastasis.Patients with positive common iliae nodes have significantly decreased 5 year disease.free survival and hishcr extra-pelvic disease recurrence rates compared with those whose common iliac nodes are negative.These findings provide impo.rtant data for design of individualized treatment mode.