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Aim of the study: The present study aimed to study histological features of different organs before and after treatment of diabetes by using avocado extract in rats. Materials and methods: Hot aqueous extraction of avocado was performed. Forty male rats (weighted 140–190g) were used in this study. Following the time of acclimatization, the animals had an overnight fast of 18 hours before being prepped for alloxan monohydrate-induced diabetes. Before and after induction, measurements of the animals’ body weights and blood glucose levels were made. However, rats received an IP injection of alloxan 150 mg/kg bw. Following that, the rats’ blood glucose levels were tracked every day for 3 weeks to establish a stable levels of blood glucose. The animals were divided into 4 groups: Group 1 got water as a non-induced (negative control) condition. Alloxan-induced rats in Group 2 received water as a positive control. Group 3: Alloxan-induced and aqueous extract-treated animals and Group 4 was only given a 40 g/L dose of the aqueous extract of avocado. Pancreas, livers, as well as kidneys from control, alloxanized, and treated rats were taken at different times, processed and utilized for histological examination after being preserved in 10% formaldehyde till processing and staining. Results: The current results showed a significant difference between different groups especially in G3 at different weeks. However, rats in G2 exhibited depleted islet cells and regions of cell necrosis. The tiny, preserved islet cells (PIL) in diabetic rats treated with extract after 1 week (G3) were an improvement as compared with rats at G2. As the days advanced, more improvements were seen in the pancreatic architecture of the rats treated with extract, including the presence of more noticeable islet cells and exocrine cells. As seen by the intact pancreatic islet in G3, caused the healing of the pancreatic tissue after 3 weeks of treatment by extracts. Alloxanized rats (G2) showed the presence of cell necrosis as well as infiltrations of inflammatory cells. However, as the course of therapy continued, it became clear that the tissue architecture had improved, and more glomeruli were seen as well as fewer inflammatory cells (G3). Livers of rats in (G2) showed visible cell necrosis, when compared to the histology of G1 and G4. After receiving medication, rats in group G3 had compact, healthy liver tissues after three weeks. In conclusion, the pancreas, kidneys, and liver were all protected by the avocado extract and showed enhancement in the histological architecture and glucose levels.
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Background: The purpose of this study was to assess the accuracy of preoperative CT imaging for predicting pathologic nodal ECE (pECE). To estimate the accuracy of the presence of radiologic extranoda AIM: l extension (rENE) in reference to pathologic extranodal extension (pENE) in patients with oral cavity squamous cell carcinoma (OSCC) MATERIALS AND METHODS: This is a prospective study in GSVM Medical College, LLR & Associated Hospitals, Kanpur (UP). The records of 50 consecutive patients with oral cavity cancer (OCC) who underwent preoperative CT imaging before initial surgical resection and neck dissection between 2020 and 2021 were reviewed. Specimens with pECE had the extent of ECE graded on a scale from 1 to 4. Radiographic ECE was RESULTS: documented in 6 patients (12%), and pECE was observed in 11 (22%). Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 45.4%, 97.4%, 83.6%, and 86.3%, respectively. The sensitivity of radio- graphic ECE increased from 40% for grade 1 to 2 ECE, to 50% for grade 3, and 50% for grade 4. Radiographic ECE criteria of adjacent structure invasion was a better predictor than irregular borders/fat stranding for pECE. Radiographic ECE has poor sensitivity, but excellent spec CONCLUSION:Radiographic ECE criteria ificity for pECE in patients who undergo initial surgical resection. PPV and NPV are reasonable for clinical decision making. The performance of preoperative CT imaging increased as pECE grade increased.
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Purpose@#Developmental disabilities (DDs) are a global childhood problem whose prevalence is rising, with a disproportionate impact on individuals in low-and middle-income countries. However, data on the prevalence of DDs in the Arab world are limited. This review highlights what is currently known about the prevalence and risk factors of DDs in preschool children in the Arab world. @*Methods@#PubMed, Cochrane Library, Scopus, CINAHL, Science Direct, and Google Scholar were searched for publications on DDs among preschool children in the Arab world. Only 14 studies were identified in the literature, from 12 Arab countries. @*Results@#The overall estimated prevalence of DDs among preschool children in the Arab world is 27.5%. An analysis of risk factors for DDs showed that child-related, maternal, and family-related factors account for a significant cumulative risk of developing DDs in preschool children. Maternal factors, such as antenatal and perinatal complications, were the most common risk factors. @*Conclusion@#The prevalence of DDs among preschoolers is significantly high in the Arab world, which emphasizes the importance of the early detection and diagnosis of DD, as well as its associated risk factors.
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ABSTRACT Objective: To assess the role of radiological predictive markers on orthopantomogram for inferior alveolar nerve (IAN) injury related to the removal of mandibular third molar surgery and the occurrence of post-operative IAN paresthesia. Material and Methods: This prospective observational study was conducted on 60 patients (aged 17-35 years) indicated for extraction and showed one or more of the seven previously known panoramic radiographic risk signs of IAN injury. Variables such as age, sex, tooth angulation, and relationship with the inferior alveolar canal (IAC) were assessed to see their outcome on IAN injury. Data analysis is presented through tables and descriptive methods. Results: Among patients, 26 were male and 34 were female, with a mean age of 26.17 years. Out of seven radiological predictive markers, only six were found in this study, whereas one marker, viz. interruption of white line of the canal was not found. After surgical removal of the lower third molar, only two patients with radiographic signs showing the deflection of roots and darkening of roots continued with sensory deficit 5 weeks post-operatively. Conclusion: The risk of inferior alveolar nerve injury during lower third molar surgery is very low, even in patients with radiological predictive markers.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Paresthesia/complications , Mandibular Nerve Injuries/complications , Molar, Third/surgery , Tooth Extraction/methods , Radiography, Panoramic/methods , Prospective Studies , Risk Factors , Observational StudyABSTRACT
Purpose: To explore straight incision technique in terms of efficacy for intraocular pressure (IOP) lowering by small-incision cataract surgery (SICS) trab versus modified 揻rown� incision with triangular scleral flap technique. Methods: This study was done at a tertiary health center. It included 44 eyes diagnosed with cataract and coexisting primary glaucoma that underwent SICS with trabeculectomy using modified 揻rown� incision with triangular scleral flap technique and straight incision in group A (n = 22) and B (n = 22), respectively. Postoperative evaluation was done at first postoperative day, then at the end of first week, third week, and 6 weeks; at the end of third month and finally at the end of sixth months. Data were entered and analyzed via Microsoft Excel sheet and SPSS software using Mann朩hitney U test for averages and Chi-square test for categorical values. Results: Mean preoperative IOP in groups A and B were 38.6 and 29.1 mm Hg respectively, by applanation tonometry. After 6-month follow-up, mean of difference in IOP (preoperative � postoperative) for group A was 20.8 � 8.3 mm Hg and that for group B was 17.2 � 13.5 mm Hg. Conclusion: Capacity of IOP reduction of both techniques was found to be comparable and did not show much difference up to the end of 6 months. Mastering technique of group A (modified 揻rown� incision with triangular scleral flap technique) requires more expertise; the simpler straight incision technique provided in group B may be effectively used by the novice and current era Ophthalmologists to combat glaucoma coexistant with cataract.
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Background/Aims@#Endoscopic ultrasonography (EUS) is warranted when cross-sectional imaging demonstrates common bile duct (CBD) dilatation without identifiable causes. This study aimed to assess the diagnostic performance of EUS in CBD dilatation of unknown etiology. @*Methods@#Retrospective review of patients with dilated CBD without definite causes undergoing EUS between 2012 and 2017. @*Results@#A total of 131 patients were recruited. The mean age was 63.2±14.1 years. The most common manifestation was abnormal liver chemistry (85.5%). The mean CBD diameter was 12.2±4.1 mm. The area under the receiver operating characteristic curve (AUROC) of EUS-identified pathologies, including malignancy, choledocholithiasis, and benign biliary stricture (BBS), was 0.98 (95% confidence interval [CI], 0.95-1.00). The AUROC of EUS for detecting malignancy, choledocholithiasis, and BBS was 0.91 (95% CI, 0.85-0.97), 1.00 (95% CI, 1.00-1.00), and 0.93 (95% CI, 0.87-0.99), respectively. Male sex, alanine aminotransferase ≥3× the upper limit of normal (ULN), alkaline phosphatase ≥3× the ULN, and intrahepatic duct dilatation were predictors for pathological obstruction, with odds ratios of 5.46 (95%CI, 1.74-17.1), 5.02 (95% CI, 1.48-17.0), 4.63 (95% CI, 1.1-19.6), and 4.03 (95% CI, 1.37-11.8), respectively. @*Conclusions@#EUS provides excellent diagnostic value in identifying the etiology of CBD dilatation detected by cross-sectional imaging.
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Background: Healthcare workers on the frontline who are directly involved in the treatment of COVID-19 patients are at a special risk of physical, psychological and social impact of the pandemic. This challenging situation is causing various mental health problems like distress, anxiety, depression, insomnia, and fear which affects their decision making ability in treating patients and also has long term physical and psychological implications. This study was aimed at investigating the psychological impact, coping strategies used and the effect of ‘brief psychological intervention’ on mental health of healthcare workers during the COVID-19 pandemic between May and October 2020. Methodology: Total 175 healthcare workers participated in the interventional study. ‘General health Questionnaire-12’ and ‘Impact of Events Scale-Revised (IES-R)’ were used to assess psychiatric morbidity and posttraumatic stress respectively; ‘brief-COPE’ was used for assessing coping strategies used. An oral session of ‘brief psychological intervention’ was delivered and reassessment by IES-R was done 3 months later. Results: Fear of spreading or contracting infection was more among females and nurses. Doctors had higher psychiatric morbidity and posttraumatic stress (PTS); there were no statistically significant gender differences in the same. Participants with higher psychiatric morbidity also had more PTS. Use of approach coping strategies showed least PTS. The interventional module was effective in stress alleviation. Conclusion: COVID-19 pandemic had led to considerable stress among healthcare workers. Imparting regular psychological intervention can help in preparedness and building resilience to tackle the taxing circumstances that have arisen due to the pandemic
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Thyroid hormones play a significant role in normal human body growth. Abnormalities in thyroid stimulating hormone (TSH) levels can result in pregnancy loss due to miscarriages and intrauterine death (IUD). The objective of the study was to assess the levels of association of thyroid stimulating hormone with miscarriages and IUD. The descriptive study involving 110 samples between 18-40 years of age fulfilling inclusion criteria were sampled for TSH testing (2ml blood) after attaining their written informed consent. The mean age of participants was 29.49±4.26 year. The prevalence of hypothyroidism and hyperthyroidism was 3.64% and 2.73%, respectively. Complications like gestational hypertension, depression and oligomenorrhea were found prevalent in these females. Majority of females were taking high/low iodine than recommended iodine level (150mcg). This work shows that there is a significant association between pregnancy loss and disturbed TSH levels among pregnant females.
Subject(s)
Thyrotropin , Abortion, Spontaneous , Intrauterine Devices , Pregnant Women , Hyperthyroidism , HypothyroidismABSTRACT
Background/Aims@#Prolonged repetitive strain caused by the continuous performance of complex endoscopic procedures enhances the risk of ergonomic injuries among health-care providers (HCPs), specifically endoscopists. This study aimed to assess the risk factors of ergonomic injuries among endoscopists and non-endoscopists. @*Methods@#This cross-sectional study was conducted at the Gastroenterology Department of Liaquat National Hospital, Karachi, Pakistan. A total of 92 HCPs were enrolled, of whom 61 were involved in endoscopic procedures and 31 were non-endoscopists. Data were collected through a self-administered questionnaire during national gastroenterology conferences and analyzed using SPSS version 22 (IBM Corp. Chicago, IL, USA). @*Results@#Of the total study population, 95.08% of endoscopists were observed to have ergonomic injuries, whereas only 54.83% of non-endoscopists had ergonomic injuries (p5 or <5 hr/wk). @*Conclusions@#Endoscopists are at high risk of developing ergonomic injuries, representing the negative potential of the endoscopy-associated workload. To overcome these issues, an appropriate strategic framework needs to be designed to avoid occupational compromises.
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Background/Aims@#Prolonged repetitive strain caused by the continuous performance of complex endoscopic procedures enhances the risk of ergonomic injuries among health-care providers (HCPs), specifically endoscopists. This study aimed to assess the risk factors of ergonomic injuries among endoscopists and non-endoscopists. @*Methods@#This cross-sectional study was conducted at the Gastroenterology Department of Liaquat National Hospital, Karachi, Pakistan. A total of 92 HCPs were enrolled, of whom 61 were involved in endoscopic procedures and 31 were non-endoscopists. Data were collected through a self-administered questionnaire during national gastroenterology conferences and analyzed using SPSS version 22 (IBM Corp. Chicago, IL, USA). @*Results@#Of the total study population, 95.08% of endoscopists were observed to have ergonomic injuries, whereas only 54.83% of non-endoscopists had ergonomic injuries (p5 or <5 hr/wk). @*Conclusions@#Endoscopists are at high risk of developing ergonomic injuries, representing the negative potential of the endoscopy-associated workload. To overcome these issues, an appropriate strategic framework needs to be designed to avoid occupational compromises.
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Abstract: This research was aimed to study the relationship between the variables of shyness and psychological well-being as the predictors of problematic internet use (PIU). The study was carried out on a sample of 400 students. The sample included 191 men (47.8%) and 209 women (52.2%) from University of Sargodha. The age range of participants in the sample was 18 to 24 years (M= 21,S.D= 4.24). The three variables of the study including shyness, psychological well-being, and problematic internet use were assessed with the shyness questionnaire, flourishing scale, and internet addiction test scale (IAT), respectively. To determine the psychometric soundness of instruments, descriptive and internal consistency levels of all the study variables were measured. The main statistical analyses included correlation, t-test, and regression analysis. The correlational analysis of overall results revealed the significant positive correlation of shyness and a significant negative correlation of psychological well-being with problematic internet use. The t-test revealed that problematic internet use and psychological well-being were significantly different according to gender. Furthermore, the results of linear regression analysis divulged that shyness positively predicts problematic internet use, while psychological well-being negatively predicts problematic internet use. Also, regression analysis on the gender indicated that being male was a predictor of greater PIU. Implications of the study along with its limitations were discussed and recommendations for further research were highly suggested.
Resumen: Esta investigación tuvo como objetivo estudiar la relación entre las variables de timidez y bienestar psicológico como predictores del uso problemático de Internet. El estudio se realizó en una muestra de 400 estudiantes. La muestra incluyó 191 hombres (47,8%) y 209 mujeres (52,2%) de la Universidad de Sargodha. El rango de edad de los participantes de la muestra fue de 18 a 24 años (M = 21, SD = 4,24). Las tres variables del estudio, incluida la timidez, el bienestar psicológico y el uso problemático de Internet, se evaluaron con el cuestionario de timidez, la escala de florecimiento y la escala de prueba de adicción a Internet (IAT), respectivamente. Para determinar la solidez psicométrica de los instrumentos se midieron los niveles de consistencia descriptiva e interna de todas las variables de estudio. Los principales análisis estadísticos incluyeron correlación, prueba t y análisis de regresión. El análisis correlacional de los resultados generales reveló la correlación positiva significativa de la timidez y una correlación negativa significativa del bienestar psicológico con el uso problemático de Internet. La prueba t reveló que el uso problemático de Internet y el bienestar psicológico eran significativamente diferentes según el género. Además, los resultados del análisis de regresión lineal divulgaron que la timidez predice positivamente el uso problemático de Internet, mientras que el bienestar psicológico predice negativamente el uso problemático de Internet. Además, el análisis de regresión sobre el género indicó que ser hombre era un predictor de mayor uso problemático de internet. Se discutieron las implicaciones del estudio junto con sus limitaciones y se sugirieron encarecidamente recomendaciones para futuras investigaciones.
Resumo: Esta pesquisa teve como objetivo estudar a relação entre as variáveis timidez e bem-estar psicológico como preditores do uso problemático da internet. O estudo foi realizado em uma amostra de400) alunos. A amostra incluiu 191 homens (47,8%) e 209 mulheres (52,2%)da Universidade de Sargodha. A faixa etária dos participantes da amostra foi de 18 a 24 anos (M = 21, S.D = 4,24). As três variáveis do estudo, incluindo timidez, bem-estar psicológico e uso problemático da internet, foram avaliadas com o questionário de timidez, escala de florescimento e escala de teste de vício em internet (IAT), respectivamente. Para determinar a solidez psicométrica dos instrumentos, foram medidos os níveis de consistência descritiva e interna de todas as variáveis do estudo. As principais análises estatísticas incluíram correlação, teste t e análise de regressão. A análise correlacional dos resultados gerais revelou a correlação positiva significativa da timidez e uma correlação negativa significativa do bem-estar psicológico com o uso problemático da internet. O teste t revelou que o uso problemático da Internet e o bem-estar psicológico foram significativamente diferentes de acordo com o gênero. Além disso, os resultados da análise de regressão linear divulgaram que a timidez prediz positivamente o uso problemático da Internet, enquanto o bem-estar psicológico prediz negativamente o uso problemático da Internet. Além disso, a análise de regressão sobre o sexo indicou que ser do sexo masculino foi um preditor de maioruso problemático da internet. As implicações do estudo juntamente com suas limitações foram discutidas e recomendações para pesquisas futuras foram altamente sugeridas.
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The diversity on fruit colouration in plants directly depends on the flavonoids that explain the development of different pigmentation patterns. Anthocyanins are the major class of flavonoid pigments that are synthesized through flavonoid biosynthetic pathway. In the present study, two genes: PgUFGT gene and R2R3-PgMYB gene, involved in anthocyanin biosynthesis were analysed in four tissues of wild pomegranate. The structural genes, UDP-glucose: flavonoid-3-O-glucosyl transferase (PgUFGT; GenBank accession number: MK058491) and its myeloblastosis transcription factor (R2R3-PgMYB; GenBank accession number: MK092063) were isolated and their expression pattern were studied. Molecular modelling indicated that the main secondary structures of PgUFGT and R2R3-PgMYB genes are α-helix and random coil. In addition, expression profiling of PgUFGTand R2R3-PgMYB by quantitative-real time PCR indicated a positive correlation between anthocyanin content and their expression in leaves, flowers, green and red fruits of wild pomegranate. Among all the tissues, the red fruit exhibited high transcripts levels of PgUFGT as well as R2R3-PgMYB transcription factor. An extensive homology with UFGTs from other plants was revealed on comparative and bioinformatic analyses. Present study reveals that PgUFGT plays a predominant role in anthocyanin content in wild pomegranate fruits. Further, it is strongly suggested that R2R3-PgMYB transcription factor regulates the anthocyanin biosynthesis in wild pomegranate via expression of PgUFGT gene. This is the first study which provides an insight on expression profile of PgUFGT and R2R3-PgMYB that are involved in colour development and fruit ripening in wild pomegranate.
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Background: Reindeer lichen, Lichen rangiferinus syn. or Cladonia rangiferina (L.) F. H. Wigg. (Cladoniaceae) has been traditionally reported as a remedy to treat fever, colds, arthritis as well as convulsions,liver infections, coughs, constipation, and tuberculosis. The current study is aimed at rectification ofalcohol induced liver damage by the use of L. rangiferinus extract.Objectives: The aim of the study was to compare some biochemical markers for liver injury and hematological indices in normal untreated rats and treated rats.Material and Methods: The study was performed using male Wistar rats. Animals were categorized intofive groups, negative control group (normal diet only), treated groups (2 groups were lichen treatedalong with 10% ethanol & 1 group was only ethanol treated) and positive control group (Silymarin + 10%ethanol) of six animals in each group. Biochemical markers for liver injury and hematological indices ofall animals were measured using standard diagnostic tools. The animals were then sacrificed and liverswere sent to the pathology lab for histopathological analysis.Results: Lichen extract showed a significant restoration of altered biochemical parameters towardsnormal in both in vitro and in vivo conditions. The total phenolic and flavonoid content of the LRE wasfound to be 21.78 mg PE/mg of extract and 5.13 mg RE/mg of extract respectively. The IC50 values foratranorin and fumarprotocetraric acid were found to be 128.48 and 218.46 mg/mL respectively.Reducing power of the extract was found to be quite significant. After administration of lichen extract,endothelial cells were less injured around central vein and number of fat vacuoles was also lesser inhepatocytes.Conclusion: Conclusively, treatment with lichen extract assuages alcohol-related damage and guardshepatic tissue from alcohol-induced toxicity.© 2017 Transdisciplinary University, Bangalore and World Ayurveda Foundation. Publishing Services byElsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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Introduction: Rupture uterus is an uncommon and frequentlycalamitous circumstance. It is connected with a highoccurrence of fetal and maternal mortality and morbidity.Objective: Our primary objective of this investigation is toassess results of uterine rupture among women with earliercesarean section.Method: This cross-sectional study was done at JalalabadRagib Rabeya Medical College Hospital, Sylhet from January2016 February to 2019 February. All out 63 instances ofruptured uterus were recorded in this investigation and everyone of the instances of ruptured uterus who were eitherconceded with complain or who developed it in medical clinicwere incorporated into the examination.Results: During the examination most events of ruptureduterus was the gestational age 37-40 weeks, (66.67%) andamong 63 patients, most (65.08%) had no antenatal checkup.(34.92%) had unpredictable antenatal checkup. Likewise therupture was bound to lower segment in the abdominal uterus.Conclusion: Lack of antenatal care, misuse of oxytocin, andinappropriate counseling of patients with history of previouscaesarian section for hospital delivery are the main causes fora ruptured uterus in this study.
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Aim: Head and neck cancers, all over the world, contribute greatly to the number of deaths, despite the advancements in the therapeutic strategies. It is characterized by locoregional disease with a tendency for metastasis to the cervical lymph nodes. The pre-operative detection of lymph node metastasis is critical for the effective treatment of patients with head and neck squamous cell carcinoma. Therefore the objective of this study was to identify E-cadherin as a marker for prediction of lymph node metastasis in head and neck squamous cell carcinoma (HNSCC).Study Design:Cross-sectional study.Place and Duration of Study: Dow University of Health Sciences, Karachi. 1 Year duration.Methodology:Cross-sectional analysis of 54 subjects with HNSCC, who underwent neck dissections, was carried out. Expression of E-cadherin was evaluated using immunohistochemical analysis and traditional histological parameters, and correlation of E-Cadherin with histologically verified presence of regional metastases was determined. Data was subjected to descriptive statistics and chi-square using Spss v.16.0.Results:54 patients included 33 males (61.1%) and 21 females (38.9%) aged from 18 to 73 (mean 44.8±12.7). A statistically significant relationship between the Downregulation of E-cadherin and histologically verified presence of nodal metastasis was established. (p value= 0.01).Conclusion:This study shows that low E-cadherin expression is useful for predicting lymph node metastases in cases of head and neck carcinoma.
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Introduction: Any pregnancy which has passed beyondexpected date of delivery (EDD) is called postdated pregnancyor prolonged pregnancy.Objective: Main goal of this study is to evaluate obstetricoutcome in postdated pregnancy.Method: This was a prospective observational type study.Patients whose pregnancy extended beyond 40 weeks ofgestational age, patients who were sure of the date of lastmenstrual period (LMP) along with 1st trimester obstetrics scanwere included for this study. Patients not sure of LMP wereexcluded in this study. The study was conducted in theDepartment of Obstetrics and Gynecology, of different privatehospital Sylhet for study duration of 3 years. Total 223 caseswere selected purposively for this study.Results: The study result shows fetus condition among the223 pregnant women highest 96.41% were alive and only3.59% were dead. Male baby and female baby was almostsame male 49.33% and female baby 50.67%. After deliverybaby admitted in hospital 76.23%, NICU 6.28% not admitted17.49%. Most of the pregnant women’s (88.34%) managementwas oligo induction failure and rest was laparoscopy. Peroperative finding of the patients shows highest 74.89% pretermpre-mature rapture of membrane, 18.83% Ectopic pregnancyand 6.28% rapture uterus.Conclusion: Postdated pregnancy having 50% risk ofrecurrence in next pregnancy. It is a high risk pregnancy thefoetal complication in the form of foetal distress, meconiumaspiration syndrome, birth trauma etc. It also increases rate ofinstrumental delivery and operative delivery.
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Background: In some settings in Saudi Arabia, many healthfacilities offer immunization without adequate knowledge ofvaccine administration and management. This may causepossible administration of nonpotent vaccines to thepopulation.Objectives: To assess cold chain system in immunizationclinics in in a sample of governmental primary health carecenters (PHCC) nurses in Makkah and to identify factorsassociated with the cold chain system.Subjects and Methods: This cross-sectional study wasconducted in Makkah city, Saudi Arabia. It included all nursesworking at immunization clinics. Self-administeredquestionnaire was adopted and modified by the researcherfrom many references, mainly PHC administrations in Jeddahand Makkah. Furthermore, the researcher reviewedquestionnaire from WHO.Results: All nurses had full marks in the knowledge test.Younger age group, graduates of Health College and lowernumbers of years of experiences were found to have betterpractice regarding cold chain. Some nurses failed to practicewhat they knew; they were older age group and graduatedfrom nurse institution.Conclusion: This study concluded that all nurses ofimmunization clinics who worked in primary health care centersin Makkah were excellent in their knowledge (100%) andpractice (>90%).
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The theme of the joint 14th World Congress of Bioethics and 7th National Bioethics Conference Congress “Health for all in an unequal world: Obligations of global bioethics” is of critical relevance in the present global context. Although the world is better off in terms of improved health status of people by many measures than before, there exist colossal gaps across and within populations. Much needs to be done to respond to the lack of access to healthcare, poor quality of living and working conditions, and deteriorating quality of overall environment which affects more adversely the already deprived. We take this opportunity to make a few observations about the current status of affairs on this front, and offer brief analytical insights into the complex origins of the global health scenario characterised by disparities. We revisit the original conception of bioethics and suggest that it is well placed to respond to the current global crisis of inexorably widening disparities in health and wealth, and that global bioethics has an obligation to engage with this crisis.
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Aims: The aim of this study was to evaluate the complexity of the chromosomal abnormalities in multiple myeloma (MM) cases and to correlate the findings with the previous reported cases. Materials and Methods: Bone marrow samples were obtained from patients with MM and sent for cytogenetic study. The patient's details were logged and the cytogenetic test was performed. The karyotypes were analyzed and interpreted as per the standard guidelines. Results: Of the compiled data of cases from 2013 to 2016, 34 patients were diagnosed with MM. About 15% were below the age of 50, maximum patients were between ages of 61 and 70 years (50%). There were 25 male and 9 female. Twenty-one cases had normal karyotypes and few cases showed structural rearrangements and numerical abnormalities. Conclusions: From the data compiled, only a total of 34 cases were positive for MM, indicating that the disease is quite rare in our population. It has been previously reported that the disease usually occurs in people over the age of 50 years, however, in this study, 5 (15%) were below the age of 50 indicating that MM can affect the age group below 50 years as well. The numerical, structural abnormalities and few clonal abnormalities observed in our study added a few more to the previously reported abnormalities. However, the interesting finding of our study was a case with a combination of clones of hypodiploidy, hyperdiploidy, hypotetraploidy, and hypertetraploidy which was in contrary to the reported literatures, which were only one type of ploidy were observed. Thus, the heterogeneity and complexity of the chromosomal abnormalities in MM and the challenge in staging the disease have been proven in our study.
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On Friday, March 9, 2018 the five-judge Constitution Bench (CB) of the Supreme Court of India (SCI) chaired by Dipak Misra, the Chief Justice of India, pronounced its judgment (1) (henceforth CC judgment) granting, for the first time in India, legal recognition to “advanced medical directives” or “living wills”, ie, a person’s decision communicated in advance on withdrawal of life-saving treatment under certain conditions, which should be respected by the treating doctor/s and the hospital. It also reiterates the legal recognition of the right to “passive euthanasia”; and draws upon Article 21 – the right to life – of the Constitution of India (henceforth Constitution) (2) interpreting robustly that the “right to life” includes the “right to die with dignity”. Justices Misra and Khanwilkar disposed of the writ petition filed in 2005 by Common Cause (3) (henceforth CC petition) saying, “The directive and guidelines shall remain in force till the parliament brings a legislation in the field” (1:p 192).