Pharmaceutical Care Measures for Improving the Safety of Chemotherapy by Clinical Pharmacists / 中国药房

OBJECTIVE:To investigate the measures and roles of pharmaceutical care in improving the safety of chemotherapy by clinical pharmacists. METHODS:Chemotherapy drug-induced ADR medical records were collected from oncology department of our hospital during Jan.-Dec. 2013 (before intervention) and Apr. 2014-Mar. 2015 (after intervention),and then analyzed and compared in respects of chemotherapy plan,patient’age and gender,route of administration,involved organs and systems,severe ADR,etc. RESULTS:After the formulation and implementation of pharmaceutical care for improving safe use of chemotherapy drugs,the incidence of chemotherapy drugs-induced ADR decreased from 88.48%to 72.14%;the incidence of ADR of involved di-gestive system,skin and its appendants decreased from 67.28% and 7.37% to 42.29% and 1.99%,respectively;the incidence of severe nausea and vomiting decreased from 27.65%to 18.91%;the constituent ratio of single agent chemotherapy and oral adminis-tration route increased from 31.80%(69/217) and 14.29%(31/217) to 44.28%(89/201) and 22.39%(45/201),respectively (P<0.05). CONCLUSIONS:Pharmaceutical care intervention measures formulated by clinical pharmacists can significantly lower the incidence of ADR,promote safe use of chemotherapy drugs and guarantee the safety of drug use.

Tube feeding with the mixture Of anisodamine and aluminium hydroxide gel to prevent and cure the upper digestive tract ulcer bleeding resulted from severe brain damage / 中华消化内镜杂志

Objective To study the effect of early administration of a mixture of Anisodamine and A-luminium hydroxide gel via nasal gastric tube in preventing in stress - induced digestive tract bleeding in patients with severe brain damage. Method One thousand one hundred and thirteen patients with severe brain damage were divided into three groups: control group 410 cases without any measures to prevent digestive tract bleeding within 72 hours after injury, treatment group A 540 cases when given cimetidine, ranitidine and Losec by intravenous injection or nasal feeding. Group B 240 cases who received nasal feeding of aniso-damine and Aluminium Hydroxide gel mixture. The incidence of bleeding in each group was recorded . Results The incidence of the upper digestive tract bleeding in group B is 1.25% , compared with that of control group( x2 = 90. 13, P