ABSTRACT
The objective of this work is to prepare flurbiprofen nanoparticles, and then incorporated into the freshly prepared gels for transdermal delivery, providing controlled release of the drug, reducing the oral side effects of the drug and for enhancing stability. Flurbiprofen is a non-steroidal anti-inflammatory drug used to treat gout osteoarthritis, rheumatoid arthritis, and sunburn. In this study Flurbiprofen nanoparticles are prepared by nanoprecipitation method. A total of 8 batches are prepared by using polymers such as ethyl cellulose, Eudragit L100 and are evaluated for various parameters. Drug-excipients compatibility was performed by FTIR study. Optimized batch of nanoparticles F3 was further formulated as gel for topical delivery. A total of 4 batches of gel were prepared using different concentrations of carbopol 934. Prepared gel formulations are evaluated for physical parameters and in vitro drug permeation study. The in-vitro release rate of gel preparations was evaluated by diffusion cell method using cellophane membrane with phosphate buffer pH Z4 as the receptor medium. F3-G1 showed highest in-vitro release rate and superior physicochemical properties. These formulations were evaluated for ex-vivo permeation study through chicken skin using Franz diffusion cell. The drug release data of optimized batch were fitted into different kinetic models which show that the drug release from gel formulations follow zero order release. The overall studies concluded that the F3-G1 Flurbiprofen nanoparticle gel can be effectively used for the treatment of chronic conditions of rheumatoid arthritis, osteoarthritis.
ABSTRACT
Transdermal drug delivery systems are a constant source of interest because of the benefits that they afford in overcoming many drawbacks associated with other modes of drug delivery (i.e. oral, intravenous). Topical gels are becoming more popular due to ease of application and better precutaneous absorption. Gels are semisolid formulations, which have an external solvent phase, may be hydrophobic or hydrophilic in nature, and are immobilized within the spaces of a three-dimensional network structure. Gel formulations provide better application property and stability in comparison to cream and ointments. Skin is one of the most extensive and readily accessible organs on human body for topical administration and is main route of topical drug delivery system. Topical gels are intended for skin application or to certain mucosal surfaces for local action or percutaneous penetration of medicament or for their emollient or protective action. Recent studies have reported other types of gels for dermal drug application, such as proniosomal gels, emulgels, bigels and aerogels. This review is concern with all detail information regarding novel approaches to topical gel formulation, advantages and classification of gel.