Soft-tissue recurrence of giant cell tumor of bone: a case report

We report a rare complication of giant cell tumor [GCT] of bone. A soft tissue recurrence without intra-osseous involvement developed in a 35-year-old lady treated for grade III GCT with intralesional excision, local adjuvant phenol and filling the cavity with bone cement. The different imaging modalities used for work-up and staging are discussed. This report emphasizes that a soft tissue recurrence may be not recognized if a thorough clinical examination is not performed and MRI is not done. Review of relevant literature addressed different factors that influence recurrence, as well as the role of osteoinductive growth factors in stimulating the osteoblastic differentiation and metaplastic bone formation in such lesions

Prophylactic fixation of impending pathological fractures due to metastatic bone disease

Management of patients with metastatic bone disease [MBD] represents a true challenge to all disciplines involved in the treatment of these patients. Pathological fracture is one of the most important skeletal related events that necessitate active orthopedic intervention. Prophylactic fixation of such fractures is less traumatic to the patients and less demanding to the surgeon. Thirty four patients with 39 impending pathological fractures due to MBD were treated by prophylactic fixation of their affected bones. Thirteen were males and 21 were females. The ages ranged from 42 to 76 years with an average of 55 years. Eighty percent of the operated patients were ambulatory immediately after surgery and nearly all of them had significant pain relief. Average hospital stay was 8 days, average operative time was 70 minutes, and complications were reported in 13 cases. The survival rate was 65% at one year, 44% at 2 years and 26% at 3 years post-operatively. Prophylactic fixation of an impending pathological fracture is technically easier, has low rate of complication and protects patients from the distress of actual fracture. A multimodality approach is important to optimize care and quality of lives to this sector of patients

Effect of mastic gum, and vitamin e on ethanol/hcl-induced gastric ulcers in rats

Gastric ulcers were induced in the rat stomach by oral administration of ethanol/HCl [150 mM HC1 in 60% ethanol, 1 ml/ 100 g]. The protective effect of mastic gum, a resinous exudate of the tree of Pistacia lentiscus Linn Anacardiaceae, [500 mg/Kg], and vitamin E, a well known antioxidant, [100 mg/Kg] were investigated. Different gastric juice components [acidity, mucin and peptic activity] as well as gastric mucosal content of reduced glutathione, malondialdehyde, [as an index of lipid peroxidation] and prostaglandin E2 were estimated. Ethanol/HCl administration produced marked ulcers in the glandular part of rat stomach. Pretreatment with the protective agents significantly reduced the ulcer index and the protection afforded by mastic gum was greater than that of vitamin E. The protective effects of both mastic gum and vitamin E were accompanied by a significant decrease in mucosal content of malondialdehyde and a significant increase in mucosal content of reduced glutathione as compared to ethanol/HCl treated group. However, the anti-ulcer effect produced by mastic gum, only, was associated with a significant increase in mucosal content of prostaglandin E[2]. In 3-hour pylorus-ligated rats, mastic gum produced a significant decrease in free and total acidity while vitamin E caused no significant change in gastric acid secretion. The present data suggest that the anti-ulcer effect of mastic gum may be partly related to its antisecretory as well as antioxidant properties. On the other hand, the protective effect of vitamin E may be mainly related to its antioxidant effect

Study of the effects of Viramune blue and fast blue on the anodic behaviour of Zn in ferric chloride solution

A great deal of interest has been paid to studies on the corrosion of zinc in various media [1-7]. Mention may be given to the corrosion of Zn in dilute aqueous solutions studied by Weast et al. [8]. The anodic and cathodic behaviour of Zn in neutral electrolytes containing Cl- ions has been studied by Kadyrov [9]. The action of some organic inhibitors were discussed by Hacker-man and Markrides [10]. The inhibitive effect of poly vinyl pyroiodine and polyvinyl pyridine on the corrosion of Zn. in sulphuric acid was investigated by Moustafa et al. [11]. The inhibitive effect of polyethylenamine has been investigated in hydrochloric acid solutions. The aim of the present work is to study the effect of variamine blue and fast blue of different concentrations on the anodic behaviour of Zn in media containing oxidizing ions as [Fe[34]], in ferric chloride solution, using anodic polarization