[ evaluation of Hirsutism at Khatam-Alanbia hospital]

Hirsutism is a common problem with the presence of terminal [coarse] hair in female, in a male-like pattern, that has different etiologic factors. This project was carried out to determine the etiologic factors of hirsutism with clinical and para clinical studies. This descriptive cross sectional study was performed at Khatam -Alanbia Hospital in Zahedan, Iran, from August 2001 to September 2003. Clinical and para clinical findings of 180 hirsute women, referred to Dermatology Clinic were evaluated. Paraclinical tests included serum testostrone, dihydroepandrostendion sulfate, thyroid stimulating hormone, follicle stimulatig hormone, luteinzing hormone, prolactin, 17-OH progesterone, and ultrasonography. Levels of one or more androgens elevated in 70 patients [39%]. Poly cystic ovary syndrome was diagnosed in 96 patients [53/3%]. A group of 80 patients [44/4%] with regular menstrual cycles and normal laboratory and sonographic findings had idiopathic hirsutism. Of patients 28, [29/2%] with poly cystic ovaries had regular menstruation. Late onset of adrenal hyper plasia, due to partial 21- Hydroxylase deficiency, was diagnosed in 4 patients [2/2%]. There are various causes of excessive hair in women. The present study's results like other studies indicated that poly cystic ovary syndrome is the most common cause and a screening work-up should be recomended on all patients with hirsutism, even women with regular menstrual cycles

[Serum lipid levels in psoriasis]

Psoriasis is a chronic inflammatory skin disorder. Several studies have indicated that psoriatic patients have higher risk for coronary heart disease and few studies focused on lipid profiles which are important in the pathogenesis of coronary heart disease. This study was designed to investigate the relationship between psoriasis and hyperlipidemia. In this case control study lipid parameters [cholesterol, Triglycerid, High density lipoprotein, Low density lipoprotein, Very low density lipoprotein] of 40 patients with moderate and severe psoriasis [study group] were compared with 40 healthy persons [control group]. Study group matched the control group considering age, sex, BMI, hypertension, habit of smoking and alcohol and body activities. In both groups 19 male and 21 female with a mean age of 37 +/- 16 were studied. Mean lipid level in case group including: TG, chol, HDL, LDL, VLDL, was respectively 105/4 +/- 48/5, 180/52 +/- 39/10, 41/22 +/- 1/87, 117/85 +/- 35/52, 21/57 +/- 10/59 and in control group was 103/8 +/- 47/95,173/92 +/- 33/41, 39/25 +/- 9/78 114 +/- 36/07, 20/62 +/- 9/57, which showed no significant difference between the two groups [p>0.05]. According to these results it seems that we don't need to investigate lipid profiles in psoriatic patients

[ comparison of the efficacy of fluconazol and griseofulvin in tinea cruris: a single blind clinical trial study]

Tinea cruris is a relatively common fungal infection. For many years Griseofulvin has been considered as the treatment of choice and now, new oral antifungal agents including Fluconazol are being used widely. The aim of this study was comparison of therapeutic effects of Griseofulvin and Fluconazol for treatment of tinea cruris. This is a single blind clinical trial study on 64 patients with tinea cruris in Dermatology Department of Ghaem Hospital between August 2004 and February 2005. All patients had clinical exam and a positive KOH test for fungal infection at first, and four and seven weeks later. Patients divided into two groups randomly: 32 patients were treated with 150mg Fluconazol once weekly and 32 were treated with Griseofulvin 500mg daily. Our data were gathered by questionnaires and were analyzed by SPSS statistecally software. On the fourth week 60% of Fluconazol group and of Griseofulvin group had clinical improvement [p=0.2], laboratory mycological studies showed that 80% of Flouconazole group and%84.4 of Griseofulvin group have had improvement [p=0.4]. Patients who had positive fungal test in the fourth week were cured clinically and paraclinically in the seventh week. There weren't any statistically significant differences between two groups. Fluconazol as like as Griseofulvin is an effective therapy for tinea cruris and it was also a simple, inexpensive and safe treatment