[Correlation between serum adiponectin level and blood glucose concentration in adult asthmatic patients]

Background: It has been hypothesized that obesity and disturbance in glucose metabolism can play an important role in the development of asthma. There is accumulating evidence in the literature that obesity can increase both the incidence and severity of asthma. Therefore, this study was conducted to determine the relationship between adiponectin, an anti-inflammatory cytokine, and blood glucose levels in overweight and obese adult patients with asthma

Materials and Methods: Forty-fine obese or overweight men [age 38-50 years] with mildto-moderate asthma referred to Saveh health centers participated in this study. Fasting blood glucose, insulin, and adiponectin levels were measured. The homeostasis model assessment [HOMA] was applied to evaluate beta-cell function using fasting glucose and insulin levels. Data were analyzed using Pearson correlation coefficient

Results: The results of this study showed that there was a significant relationship between the serum adiponectin and FEV1/FVC, FEV1 and FVC in asthma patients. In addition, serum adiponectin level was positively correlated with insulin and beta-cell function, but negatively with fasting glucose level

Conclusion: According to the results, there is a negative correlation between serum adiponectin levels and blood glucose concentration in adult asthmatic patients. Furthermore, our findings showed that the reduction of systemic adiponectin level influences blood glucose concentration via insulin level and beta-cell function

[Relation between serum ghrelin concentration and blood glucose levels in type-2 diabetic obese males]

Ghrelin is an acylated 28-amino-acid peptide that is the most recently identified adipocytokines, but its role in diabetes is poorly clarified. The objective of this study was to determine the relation between serum ghrelin and blood glucose levels in type 2 diabetic obese males. This descriptive study was done on 45 adult obese males with type-2 diabetes in Saveh city, Iran during 2010. Fasting blood glucose, insulin and ghrelin concentrations and Glycosylated hemoglobin HbA1C were measured after overnight fasting. Multiple regression was used for determine ghrelin in relation to glucose, insulin and HbA1C. The multiple regression analyses revealed that HbA1C is not correlated with serum ghrelin levels, while, fasting blood glucose level had positive corrolation with serum ghrelin concentration [P<0.05]. Serum ghrelin level had high negative correlation with insulin [P<0.05]. This study indicated that elevated endogenous ghrelin led to hyperglycemia. Therefore, serum ghrelin is a precise index of blood glucose level in obese male patients with type-2 diabetes

[Investigation of the relationship between adiponectin and beta-cell function in patients with type II diabetes]

Although both insulin resistance and beta cell dysfunction contribute to pathogenesis of type II diabetes, the role of adiponectin in beta cell function has received limited attention. The objective of this study was to determine the relationship between serum adiponectin level and beta cell function. Forty one non athletes fat adult men between 35 and 50 years of age [BMI >/= 30] with type II diabetes were enrolled in this study. Serum concentrations of adiponectin, glues, triglyceride and insulin were measured after 10-12 hours overnight fasting in all participants. Beta cell function was assessed by measuring fasting glucose and insulin level. After data collection, we used Pearson correlation test to determine the relationship between adiponectin and beta-cell function in patients with type II diabetes [p

[ effect of chronic intake of L-carnitine L-tartrate on lipid metabolism during aerobic exercise]

Despite 20 years of research, there is no compelling evidence about the effect of carnitine supplementation on improving physical performance in healthy subjects. The aim of this study was to determine the effect of long term consumption of acute L-carnitine L-tartarate [LCLT] on fat metabolism and aerobic capacity. A total of 28 healthy nonathlete male students received either L-carnitine L-tartarate or placebo [Lactose] for 3 weeks [3g orally, daily] in experimental and control groups. The subjects of both groups performed submaximal ergometery Astrand protocol on bicycle for 20 minutes before and after this supplementation period. Following each test, blood samples were drawn immediately to determine the concentrations of plasma free fatty acid [FFA], triglyceride [TG] and other metabolites. Resting and submaximal heart rates were monitored. The collected data of pre and post tests were evaluated by SPSS 13.0 software in the both groups. No significant differences in FFA, TG and resting and exercise heart rates were found between pre and post tests in the both experimental and control groups.Three weeks LCLT supplementation has no effect on fat metabolism and aerobic capacity. Also, chronic intake of LCLT has no effect on substrate utilization or endurance performance in healthy individuals