Acetals I. cyclohexylidenation of glycerolyl flavazoles and the galactosyl derivative of the D-erythro analogue

Cyclohexylidenation of 3-[D and L-threo-glycerol-1-yl]-phenylflavazole gave in both cases 2 products, alpha-terminal and alpha-threo- cyclohexylidene rings which afforded the corresponding monoacetyl derivatives upon acetylation. Similarly 3-[D-erythro- glycerol-1-yl]-1-phenylflavazole gave 2,3-O-cyclohexylidene derivative, which formed an acetate upon acetylation. While 3-[1-O-[beta-D-galactopyranosyl]-D-erythro- glycerol-1-yl]-1-phenylflavazole gave the corresponding 3',4',2,3-di-O- cyclohexylidene derivative, whose acetylation and oxidation were studied

Isopropylidenation of sugar osazones

Acetonation of D-erythro- and L-erythro- pentose phenylosazone afforded the respective alpha-terminal isopropylidene derivatives 2 and 6 respectively. Their acetylation gave the corresponding 3-O-acetyl-4, 5-O-isopropylidene derivatives 3 and 7, respectively. Benzoylation of 2 afford the dibenzoyl derivative, 3-O-benzoyl-4, 5-0-isopropylidene-D-erythro-N-benzoyl-pentose phenylosazone [4]. Acetonation of D-threo-pentose phenylosazone [8] gave two products of the alpha-terminal and alpha-thre isopropylidene derivatives 9 and 10, respectively. Acetylalion of 10 and benzoylation of 9 gave the respective monoacetyl, and dibenzoyl derivatives 12 and 11, respectively. Acetonation of D-arabino-hexose phenylosazo-ne [13] afforded the mono- and di-isopropylidene derivatives 14 and 15 reapectively. Acetylation of 14 gave 3, 4-di-O-acetyl derivative 18. Isopropylidenation of D-lyxo-hexose phenylosazone [17] afforded the monoisopropylidene 18, which gave -upon acetylation the corresponding 3, 4-di-O-acetyl derivative 19

Variation of the intraocular pressure with errors of refraction

This study included 200 patients [400 eyes] aged between 15- 40 years. One hundred patients were selected to be myopes and another 100 to be hypermetropes. All glaucomatous patients were excluded. IOP was measured using applanation tonometer and Schiotz tonometer [5.5g., 7g.]. Refraction was done under cycloplegic effect [1% cyclopentolate hydrochloride]. Data were summarized and it was concluded that the mean IOP by applanation tonometry is lower than that measured by Schiotz method and that the mean IOP in the left eye was lower than that of the right eye