Effect of organophosphorus insecticide on immune system in experimental animals

The immunotoxic effect of repeated sublethal doses of trichlorfon was studiedby using 512 male Lewis mice. They were divided into 4 control groups [n =32] received distilled water and 4 test groups [n = 96] received trichlorfon[an organophosphorous insecticide] in daily oral doses for 15, 30, 45 and 60days, respectively. Each test group was divided into 3 equal subgroupsaccording to trichlorfon dose [30, 60 and 90 mg/kg body weight, respectively]. The degree of immunotoxicity was studied by determining serum immunoglobulinsconcentrations, the percentage of lymphocyte blastogenesis, phagocyticpercentage and index. The phagocytic percentage showed a significantreduction with low dose for 45 and 60 days and for all durations with mediumand high doses. Phagocytic index reduction following the low dose for 30, 45and 60 days was significant and for all durations with medium and high doses

Diagnostic value of plain radiography and myelography in lumbar canal stenosis

The records of seventy six patients with surgically proven lumbar canal stenosis were analysed. Clinical features, plain radiography and myelography of the lumbar spine were studied. Plain x-ray abnormalities suggesting spinal canal stenosis were positive in 66 cases [78.9%]. Myelography was correct in 67 eases [88.2%]

Clinico - epidemiological study of congenital talipes equinovarus

This study was carried out on 73 patients with congenital talipes equinovarus attending the Orthopaedic and Paediatric Departments, Mansoura University Hospital. Careful history, clinical and radiological examination and chromosomal study was carried out for every patient in order to detect the aetiology and the genetic pattern of club foot. We concluded that idiopathic club foot is primarily caused by multifactorial inheritance system modified by intrauterine environmental factors and is affected by the genetic pattern

Plate and screws fixation in treatment of hand fractures

This work was carried out in Orthopedic Department, Mansoura University Hospital since 1987. 48 patients with 66 fractures and 22 fracture proximal phalanx were treated by O.R.I.F. by mini plate and screws. Results were evaluated. It was proved that this is a good method of treatment of hand fractures. Factors affecting the end results were recorded

Total excision versus osteosynthesis in treatment of comminuted and displaced fracture patella

This work was done in Orthopedic Department, Mansoura University Hospital. 45 cases with comminuted displaced fracture patella were included. 22 were treated by total patellectomy. 23 were treated by open reduction and internal fixation by different methods [10 circulage wiring, 8 tension bond wiring and 5 screw fixation]. Results were evaluated in both groups. It was proved that internal fixation had better results than total patellectomy

Effect of endotoxin on ovulation, implantation and early foetal development in rabbits

Salmonella entritidis endotoxin given in a dose of 1 ml/kg [= 20 ug/kg] intravenously to female rabbits five hours after chotionic gonadotropin administration caused significant reduction in the number of ruptured follicles. The simultaneous administration of the same dose of endotoxin with 2 mg/kg indomethacin intra-muscularly did not reverse the effect of endotoxin on ovulatory process. To study the effect of endotoxin on implantation and early foetal development, it was given in a dose of 0.25 ml/kg [= 5 ug/kg] intravenously on day 4 of gestation and this resulted in failure of implantation. On combining endotoxin and indomethacin, the effect of endotoxin on implantation was not reversed. Endotoxin administration on day 8 of gestation produced a lethal effect on most of foetuses and regression of associated placentae. When indomethacin was combined with andotoxin on day 8 of gestation, the immediate lethal action was inhibited as evidenced by presence of most implantations at the time of autopsy on day 14. Nevertheless, most foetuses died after indomethacin treatment. Administration of indomethacin alone on day 4 of pregnancy did not reduce the total number of foetuses, but foetuses and placental tissues were smaller than controls. However indomethacin given on day 8 of pregnancy resulted in a large number of post implantation mortalities. The results are discussed and it was recommended that: First: Women desirous of becoming pregnant or pregnant women early in their gestation should be advised not to use the analgesic agent indomethacin particularly prior to ovulation and during the luteal phase of the menstrual cycle. Second: If a lady is suffering from a disease caused by an endotoxin producing organism she must use a contraception to prevent her from becoming pregnant and if she is already pregnant, gestation must be terminated