Evaluation of the role of lipase activity on cholecystokinin release, gastric emptying and pancreatic secretion

These studies shown that lipase plays an important nutrient specific regulatory role on upper gastrointestinal functions which is dependent on the hydrolysis of fat into free fatty acids, thus stimulating the release of CCK. The studies showed also the high potency and specificity of THL as a lipase blocker. Since pancreatic lipase is the first enzyme to show a decrease in activity in patients with pancreatic insufficiency, the results of our study are important for evaluating some pathophysiological aspects of this disease. In the current study can be used in the pharmacotherapy of diseases related to dietary fat intake such as obesity, hypercholesterolemia, and their sequelae