ABSTRACT
To evaluate the disease characteristics and treatment outcome of children with wilms' tumorat King Hussein Medical Center over a period of 10 years. We conducted a retrospective review of the medical files of children [< 14 years] withwilms' tumor who were managed at King Hussein Medical Center -Jordan in the interval between June,2000 until June, 2010 . Patients' and disease characteristics, treatment modalities and outcome wereanalyzed. Staging and histopathological classification were preformed according to the system of theNational Wilms Tumor Study Group [NWTSG]. Descriptive analysis using frequencies was used todescribe the study variables. A total of 61 patients [54.1% female] with wilms' tumor with a median age of 40 months wereidentified. Their ages ranged between seven months and 7.8 years. The stage frequencies of our caseswere: stage I [27.9%], stage II [34.4%], stage III [16.4%], stage IV [11.5%] and stage V [9.8%] . The 3- year relapse-free survival rate was 100%, 81%, 70%, 57.1% and 83.3% for stages I, II, III, IVand V, respectively. Favorable histology accounted for 86.9% [53 cases] of our patients . The 3-yearrelapse-free survival rate was 84.9% for the favorable histology and 62.5% for the anaplastic histology.The 3- year relapse-free survival rate for the entire group was 82%.Combined modality management including surgery, chemotherapy and radiotherapyresulted in satisfactory loco-regional and systemic control and better relapse-free survival in pediatricpatients with wilms' tumor . Stage and histopathologic classification of the disease were important asprognostic factors