ABSTRACT
Biological and chemical stimulators cause tissue injury. Many epidemiological studies imply that chronic stimulation of tissues leads to cancer. One of the most important type of chronic tissue stimulation criteria is increased activity of the metabolic pathway of arachidonic acid and production of biochemical intermediates. Cyclooxygenase pathway [COX] of arachidonic acid leads to production of a variety of prostaglandins and thromboxanes. These inflammatory agents exert their biological effects on different organs and initiate human cancers. Lately, a variety of synthetic and natural drugs have been discovered that suppress the production of these inflammatory agents and inhibit cancer promotion. One of the most popular drugs, are nonsteroidal anti-inflammatory drugs, [NSAIDs]. In this review, we discuss the role of these inflammatory agents in colorectal carcinogenesis and also their mechanism of inhibition