ABSTRACT
The kidney has a key role in homeostatic regulation. Vascular endothelial growth factor [VEGF] is essential regulator of stimulatory and inhibitory processes for neonatal, post-natal endothelial cell differentiation. This study was done to determine the effect of maternal swimming during pregnancy on VEGF level of kidney in rat pups. In this experimental study, sixteen Wistar rat dams were allocated into interventional swimming and control groups. In the first day of pregnancy, in interventional group, swimming was performed for 30 minutes a day and 5 minutes every day was added until the time of training gradually reached to one hour per workout. Dams swimming endurance training were performed in 5 days per week for three weeks. Pups' kidneys were removed two days after birth and kindney tissue VEGF level was determined using ELISA method. Kidney tissue VEGF level in interventional swimming group [133.13 pg/ml] was significantly increased in compared to controls [48.19 pg/ml] [P<0.05]. Swimming endurance training increases the pups' kidney VEGF level
ABSTRACT
There are some information about antimicrobial and anti-inflammatory effect of Matricaria chamomilla flower oil extract, but there isn't any information about its effect on linear incisional wound healing. In this investigation, the effect of Matricaria chamomilla flower oil extract on linear incisional wound healing was studied. Thirty male Wistar rats were subjected to a linear 3cm incision made over the skin of the back. The animals were randomly divided into 3 experimental groups, as Sham operated, Control [Olive oil] and treatment. Sham group did not receive any treatment. Control group received topical olive oil twice a day from beginning of experiments to complete wound closure. Treatment group were treated topically by M. chamomilla extract dissolved in olive oil at the same time. For computing the percentage of wound healing, the area of the wound measured at the beginning of experiments and the next 2, 5, 8, 11, 14, 17 and 20 days. The percentage of wound healing was calculated by Walker formula after measurement of the wound area. Results showed that there were statistically significant difference between treatment and Control animals [p < 0.05] in most of the days. We conclude that the topical administration of M. chamomilla extract has wound healing potential in linear incisional wound model in rats
Subject(s)
Male , Animals, Laboratory , Plant Extracts/pharmacology , Rats, Wistar , Drug Evaluation, Preclinical , /drug effects , Wounds and Injuries/therapy , Administration, Topical , SkinABSTRACT
Background and Purpose: Cuminum Cyminm [CC] is one of the plants whose aqueous extract is used in traditional medicine as anti-convulsive, anti-epileptic and as a tretment for some visceral pains. However, no substantial reports can be found of its effects on the peripheral pain in lab animals. Therefore, this study was condcated to determine the eefects of the IP injection of the aqueous extract of CC on the acute peripheral pain in Hot Plate [HP] and Tail Flick [TF] tests in mice
Methods and Materials: This experimental study was conducted on 56 male Albino mice [8 groups each with 7 mice] weighing 25-30 gr. 200 and 500 mg/kg of the aqueous extract of CC or saline of the volume were injected intraperitoeally 30 minutes prior to the tests. Pain measrment criteria in the TF test was the response time to the pain by raising the tail, and in the HP test the time to begin to lick the front legs or raising the rear feet
Results: The IP injection of the CC aqueous extract with the doses of 200 and 500 mg/kg significantly increasd the response time to the pain in HP and TF tests [P<0.01] in cmparison with the control groups and the group receiving saline. The efect was however more remarkable with the 500 mg/kg dose
Conclusion: The results of this study indicated that the aqueous extract of CC reduced the acute peripheral pain in the mice
ABSTRACT
Portulaca oleracea [PO] overgrows in different parts of Iran. In previous studies, a 10% hydroalcoholic extract of the PO aerial parts [leaf and stem] showed anticipative and anticonvulsive activity in rats. This study was designed to evaluate anxielytic effects in different doses of the aqueous decoction extracts of PO seed. In this study, forty male mice [25-30gr] were used in a model elevated plus maze [EMP]. Different doses of the extract [25, 50, 75 mg/kg] were injected intraperitoneally [IP] to three separated test groups and normal saline [10 ml/kg, IP] was injected to one control group, intraperitoneally. For increasing their activity, animals were put inside a black box for 5 min. Then they were transferred to the elevated plus maze and evaluated for their anxiety reaction, including number and percent of time spent in open arm. Results indicated that injection of the extract in three doses of PO reduced anxiety reaction in test groups, compared with the control group which had higher number of entrances and spent more time in open arm [P=0.000]. It is suggested that the aqueous extract of PO plays an important role in fear and anxiety reactions and that the anxielytic effects of PO is not related to the dosage of use
Subject(s)
Animals, Laboratory , Plant Extracts , Anti-Anxiety Agents , MiceABSTRACT
Since use of synthetic drugs for relief of pain has many side effects, today medical plants are becoming more prominent as substitute therapeutic agents. Previous findings indicate that Coriandrum sativum [CS] modulates pain in both animal and human. The present work investigated the effects of CS seed on acute pain using hot plate and tail flick models. Albino mice [25-30 g] were used for this study. Aqueous extract of CS seed was injected in doses of 100 and 200 mg/kg 30 min before test. The analgesic effect of the drug on acute pain was evaluated using Hot plate and Tail flick models. Results indicated that CS has analgesic effect in both doses in both models and higher dose of the drug was more effective [p<0.01]. The findings above showed that CS could modulate acute pain. Further research is required to determine the mechanisms by which CS has an inhibitory effect on pain sensation
Subject(s)
Animals , Plant Extracts , Pain/therapy , Mice , Treatment OutcomeABSTRACT
The side effects of anti-nociception chemical drugs caused notice to medical plants. This study was performed to investigate the effects of hydroalcoholic extract of Thymus vulgaris [TV] on neurogenic and inflammatory pain in formalin test in mice. 40 male albino mice [20-30 gr] were used. TV [100, 500 mg/kg] as extract and saline were injected 30 mine before formalin test. Indexes for evaluation were duration of licking and foot elevation for assessment of acute pain [5 min] and chronic pain [15-40 min] after injection of formalin 5% [25 microl] in paw. Results indicated that TV has analgesic effect in both doses [P<0.01], and higher dose [500 mg] was more effective. Findings showed that hydroalcoholic extract of TV can modulate acute and chronic pain. Further research is required to determine the mechanisms by which TV has an inhibitory effect on pain sensation
ABSTRACT
Since uses of antinoceception chemical drugs for relief of pain have many side effects; today medical plants are very noticeable. The present work investigated the effects of Hydroalcoholic extract of Thymus vulgaris [TV] on acute pain in Hot plate and Tail flick models. Albino mice [20-30 gr] were used for this study. Hydroalcoholic extract of TV seed was injected in doses of 100 and 500 mg/kg 30 min before test. Then the analgesic effect of the drug on acute pain was evaluated using Hot plate and Tail flick models. Results indicated that TV has analgesic effect in both doses in both models [P<0.01], and higher dose of the drug was more effective. These findings showed that TV could modulate acute pain. Further research is required to determine the mechanisms by which TV has an inhibitory effect on pain sensation