ABSTRACT
Organ transplantation is revolutionized since production of cyclosporine. Considering the increased incidence of cytomegalovirus [CMV] infection in patients with transplantation, this study is designed to evaluate the relationship between cyclosporine blood level in patients undergone kidney's transplantation and the rate of CMV infection. This retrospective descriptive study evaluated 511 kidny's transplanted patients for cyclosporine blood level and rate of CMV infection during 100 postoperative days in Labbafinejad hospital [2001-2003]. 57 [11%] out of 511 developed CMV infection. The minimum interval between surgery and infection was 20 days, the maximum interval was 99 days with a mean of 56 days. Mean blood cyclosporine levels in infected and non-infected patients were 383.3 and 310 ng/ml respectively. This difference was statistically significant [p<0.05]. We conclude that CMV infection is closely related to cyclosporine blood level. In order to obtain more efficacy and less cytomegalovirus infections, careful cyclosporine blood level monitoring [<300 ng/ml] is recommended
ABSTRACT
Crimean-Congo Hemorrhagic Fever is a fatal viral disease that occurs in some parts of Africa, Asia, Eastern Europe and the Middle-East. Primarily it is a zoonosis but can be seen sporadically in humans. Recently outbreaks have been reported from Pakistan, Afghanistan, Saudi Arabia, United Arab Emirates and Iran. In this retrospective study, we evaluated the efficacy of oral Ribavirin in the treatment of CCHF cases, by comparing the outcome in two groups of treated and non-treated confirmed CCHF cases. 81 confirmed CCHF cases [by serology or viral culture] were evaluated for the incidence of outcome [death or recovery] in the form of an analytic case-control study. 61 out of 69 treated cases and 5 out of 12 non-treated cases survived. Oral Ribavirin with an efficacy of 91% can be an effective medical therapy for management of Crimean Congo Hemorrhagic Fever