ABSTRACT
Background and Purpose: It has been suggested that intracellular adhesion molecules [sICAM-1], as a new inflammatory marker, are more precise and sensitive markers in predicting cardiovascular diseases, compared with traditional predictive markers. The purpose of this investigation was to study the effect of discontinuous endurance exercise on sICAM-1 and lipid profile [LDL-C, HDL-C, TG, and TC] of non-athletic male students and to survey the correlation between changes of these variables
Material and methods: This experimental study involved twenty non-athletic male students who signed the written informed consent, and were randomly assigned into experimental [n=12] and control [n=8] groups. The exercise protocol was a graded program, to be performed for 8 weeks three times per week with specific intensity and duration. Blood samples were taken before the first session and after the last session, with 14 hours fasting. Data were analyzed in SPSS 16 using independent and dependent t-test, and Pearson correlation coefficient to determine the correlation of the variables. Level of statistical significance was set at ?<0.05
Results: Eight weeks of discontinuous endurance exercise caused 14% decline in sICAM-1 [p=0.0001], 6% in TC [p=0.001], 10% in LDL-C [p=0.0001], 40% in TG [p=0.0001] and 23% increase in HDL-C [p=0.001] in the experimental group. However, there were no significant correlation between sICAM-1 alteration and changes of traditional predictors of cardiovascular diseases [LDL-C, HDL-C, TG, and TC] [p>0.05]
Conclusion: Eight weeks of discontinuous endurance exercise may reduce sICAM-1 and improve the lipid profile. These changes can play effective roles in the prevention, control and treatment of atherosclerosis
ABSTRACT
Post-operative edema and trismus are common following removal of impacted teeth. The aim of the present study was to compare the effects of local and intravenous [W]dexamethasone on the edema and trismus following hard tissue impacted mandibular third molar teeth surgery. In this clinical trial, 20 patients were randomly selected and allocated into two treatment groups. Surgical removal of bilateral impacted mandibular third molars under local anesthesia was performed. Group A received 8mg IV dexamethasone and group B received 4mg local infiltrated dexamethasone for each side. Edema was measured using both tape measure and sonography methods. In regards to trismus, interincisal mouth-opening was measured using a calibrated caliper pre-operatively and post-operatively. Data were statistically analyzed using Mann- Wittney and Wilcoxon tests. Both sonography and tape measure [method A] methods showed that the local dexamethasone was significantly more effective than IV dexamethasone in reduction of post-operative edema [p=0.012]. Meanwhile, the - difference of effectiveness between local and IV dexamethasone on the trismus was not statistically significant. The results indicated that the use of local dexamethasone is an effective therapeutid strategy in reduction of post-operative edema of mandibular third molar teeth surgery