ABSTRACT
Metabolic syndrome is a prevalent non-communicable disease in the present era. It manifests as obesity, impaired fasting blood glucose, dyslipidaemia, and hypertension. Hypothyroidism causes hypertension, dyslipidaemia, and impaired carbohydrates metabolism, which are all components of metabolic syndrome. The cardiovascular system is very sensitive to thyroid hormones. METHODSA cross sectional study was conducted from October 2017 to March 2019 in adult population aged 18 years and above, with features of Metabolic syndrome diagnosed according to National Cholesterol Education Programme Adult Treatment Panel – III (NCEP ATP III) criteria. Study was conducted in the department of general medicine, GSL Medical College and General hospital, Rajahmundry, Andhra Pradesh. RESULTSIn a total of 134 patients with metabolic syndrome, 39 were male (29.2%) and 95 were female (70.8%). The mean age of the study population was 54.63 ± 10.9 years. The prevalence of thyroid dysfunction in the present study is 28.4%. In the present study, metabolic syndrome is found to be significantly (p=0.032) associated with thyroid dysfunction. CONCLUSIONSBoth hypothyroidism and hyperthyroidism are associated with cardiovascular manifestations. Hypothyroidism and subclinical hypothyroidism cause cardiovascular manifestations along with metabolic changes. Investigating the thyroid function status may be considered as a part of screening in patients with metabolic syndrome.
ABSTRACT
Hyperuricaemia may be associated with an increased risk of stroke, but updated results from several studies have been inconsistent. The present study aimed to evaluate the relationship between hyperuricaemia & risk of stroke.METHODSThis cross-sectional study was conducted in the Department of General Medicine, GSL Medical College and General Hospital, Rajamahendravaram, with a total of 144 stroke patients. Other risk factors were also noted and serum uric acid (SUA) levels were determined.RESULTSThere was a significant (p<0.05) difference in the mean levels of different categories of age and increased levels of SUA levels in both males and females. There was a significant association between hypertension, diabetes mellitus, dyslipidaemia, CAD, but no significant relationship with (p>0.05) history of cerebrovascular accident (CVA), smoking and alcohol consumption. There was a significant association (p<0.05) between stratified SUA levels (normal and hyperuricaemia) and hypertension, diabetes mellitus, dyslipidaemia, coronary artery disease (CAD) and age, but no significant (p>0.05) association with history of CVA, smoking and alcohol consumption.CONCLUSIONSElevated SUA level is a significant risk factor for stroke. elevated serum uric acid level needs to be interpreted carefully in patients with risk factors for vascular events like hypertension, diabetes mellitus, dyslipidaemia and a history of prior vascular events. The prevalence of hyperuricaemia was found to be high especially in patients in their seventh decade of life and later.